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Sonderforschungsbereich 699

Strukturelle, physiologische und molekulare Grundlagen der Nierenfunktion


Anzahl der Publikationen: 381

Benedetto R, Ousingsawat J, Wanitchakool P, Zhang Y, Holtzman MJ, Amaral M, Rock JR, Schreiber R, Kunzelmann K
Epithelial Chloride Transport by CFTR Requires TMEM16A
Sci Rep. 2017 Sep 29;7(1):12397
Cabrita I, Benedetto R, Fonseca A, Wanitchakool P, Sirianant L, Skryabin BV, Schenk LK, Pavenstädt H, Schreiber R, Kunzelmann K
Differential effects of anoctamins on intracellular calcium signals.
E Schinner, V Wetzl, A Schramm, F Kees, P Sandner, JP Stasch, F Hofmann F, J Schlossmann
Inhibition of the TGFbeta signalling pathway by cGMP and cGMP-dependent kinase I in renal fibrosis.
FEBS Open Bio. 2017 Mar 1;7(4):550-561.
Hagmann H, Mangold N, Rinschen MM, Koenig T, Kunzelmann K, Schermer B, Benzing T, Brinkkoetter PT
Proline-dependent and basophilic kinases phosphorylate human TRPC6 at serine 14 to control channel activity through increased membrane expression.
FASEB J. 2017 Sep 6. pii: fj.201700309R. doi: 10.1096/fj.201700309R. [Epub ahead of print]
Kunzelmann K, Schreiber R, Hadorn HB
Bicarbonate in cystic fibrosis.
J Cyst Fibros. 2017 Jul 18. pii: S1569-1993(17)30807-X. doi: 10.1016/j.jcf.2017.06.005. [Epub ahead of print]
Schlossmann J, Wolfertstetter S
Identification of cCMP and cUMP Substrate Proteins and Cross Talk Between cNMPs
Handb Exp Pharmacol. 2017;238:149-167.
Simões F, Ousingsawat J, Wanitchakool P, Fonseca A, Cabrita I, Benedetto R, Schreiber R, Kunzelmann K
CFTR supports cell death through ROS-dependent activation of TMEM16F (anoctamin 6).
Pflugers Arch. 2017 Sep 5. doi: 10.1007/s00424-017-2065-0. [Epub ahead of print]
Wetzl V, Schinner E, Kees F, Faerber L, Schlossmann J
Differences in the renal antifibrotic cGMP/cGKI-dependent signaling of serelaxin, zaprinast, and their combination.
Naunyn Schmiedebergs Arch Pharmacol. 2017
Angermeier E, Domes K, Lukowski R, Schlossmann J, Rathkolb B, Angelis MH, Hofmann F
Iron deficieny anemia in cyclic GMP kinase knockout mice
Haematologica 2016 Feb;101(2):e48-51.
Assmann N, Dettmer K, Simbuerger JM, Broeker C, Nuernberger N, Renner K, Courtneidge H, Klootwijk ED, Duerkop A, Hall A, Kleta R, Oefner PJ, Reichold M, Reinders J
Renal Fanconi Syndrome Is Caused by a Mistargeting-Based Mitochondriopathy.
Cell Rep. 2016 May 17;15(7):1423-9.
Baig AA, Haining EJ, Geuss E, Beck S, Swieringa F, Wanitchakool P, Schuhmann MK, Stegner D, Kunzelmann K, Kleinschnitz C, Heemskerk JW, Braun A, Nieswandt B
TMEM16F-Mediated Platelet Membrane Phospholipid Scrambling Is Critical for Hemostasis and Thrombosis but not Thromboinflammation in Mice-Brief Report
Arterioscler Thromb Vasc Biol. 2016 Nov;36(11):2152-2157. Epub 2016 Sep 15.
Benedetto R, Sirianant L, Pankonien I, Wanitchakool P, Ousingsawat J, Cabrita I, Schreiber R, Amaral M, Kunzelmann K
Relationship between TMEM16A/anoctamin 1 and LRRC8A
Pflugers Arch. 2016 Aug 12. [Epub ahead of print]
Castrop H, Schießl IM.
Novel Routes of Albumin Passage Across the Glomerular Filtration Barrier.
Acta Physiol (Oxf). 2016
Castrop H.
Tubuloglomeruläres Feedback
Der Nephrologe, 10.1007/s11560-015-0039-9, 2016
Grill A, Schießl IM, Gess B, Fremter K, Hammer A, Castrop H.
Salt-Losing Nephropathy in Mice with a Null Mutation of the Clcnk2 Gene.
Acta Physiol (Oxf), 2016
[Pubmed] [Editorial]
Kraus A, Grampp S, Goppelt-Struebe M, Schreiber R, Kunzelmann K, Peters DJ, Leipziger J, Schley G, Schödel J, Eckardt KU, Buchholz B
P2Y2R is a direct target of HIF-1α and mediates secretion-dependent cyst growth of renal cyst-forming epithelial cells
Purinergic Signal. 2016 Aug 26. [Epub ahead of print]
Kunzelmann K, Cabrita I, Wanitchakool P, Ousingsawat J, Sirianant L, Benedetto R, Schreiber R.
Modulating Ca2+ signals: a common theme for TMEM16, Ist2, and TMC
Pflugers Arch. 2016 Mar;468(3):475-90
Kunzelmann K.
Ion channels in regulated cell death.
Cell Mol Life Sci.
Mattheij NJ, Braun A, van Kruchten R, Castoldi E, Pircher J, Baaten CC, Wülling M, Kuijpers MJ, Köhler R, Poole AW, Schreiber R, Vortkamp A, Collins PW, Nieswandt B, Kunzelmann K, Cosemans JM, Heemskerk JW
Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage.
FASEB J. 2016 Feb;30(2):727-37
Mederle K, Gess B, Pluteanu F, Plackic J, Tiefenbach KJ, Grill A, Kockskämper J, Castrop H.
The angiotensin receptor-associated protein Atrap is a stimulator of the cardiac Ca2+-ATPase SERCA2a.
Cardiovasc Res, epub ahead of print, 2016
Otaño-Rivera V, Boakye A, Grobe N, Almutairi MM, Kursan S, Mattis LK, Castrop H, Gurley SB, Elased KM, Boivin GP, Di Fulvio M.
A highly efficient strategy to determine genotypes of genetically-engineered mice using genomic DNA purified from hair roots.
Lab Anim, 2016, epub ahead of print
Ousingsawat J, Cabrita I, Wanitchakool P, Sirianant L, Krautwald S, Linkermann A, Schreiber R, Kunzelmann K
Ca2+ signals, cell membrane disintegration, and activation of TMEM16F during necroptosis
Cell Mol Life Sci. 2016 Aug 17. [Epub ahead of print]
Schießl IM, Castrop H.
Deep insights: intravital imaging with two-photon microscopy.
Pflugers Arch, 2016
Schreiber R, Kunzelmann K
Expression of anoctamins in retinal pigment epithelium (RPE)
Pflugers Arch. 2016 Nov 7. [Epub ahead of print]
Sirianant L, Wanitchakool P, Ousingsawat J, Benedetto R, Zormpa A, Cabrita I, Schreiber R, Kunzelmann K.
Non-essential contribution of LRRC8A to volume regulation.
Pflugers Arch. 2016 Feb 13. [Epub ahead of print]
Sommer A1, Kordowski F1, Büch J1, Maretzky T2, Evers A2, Andrä J, Düsterhöft S, Michalek M, Lorenzen I, Somasundaram P, Tholey A, Sönnichsen FD, Kunzelmann K, Heinbockel L, Nehls C, Gutsmann T, Grötzinger J, Bhakdi S, Reiss K.
Phosphatidylserine exposure is required for ADAM17 sheddase function.
Nat Commun.
Wanitchakool P, Ousingsawat J, Sirianant L, Cabrita I, Faria D, Schreiber R, Kunzelmann K
Cellular defects by deletion of ANO10 are due to deregulated local calcium signaling
Cell Signal. 2016 Nov 9. pii: S0898-6568(16)30265-0. doi: 10.1016/j.cellsig.2016.11.006. [Epub ahead of print]
Wanitchakool P, Ousingsawat J, Sirianant L, MacAulay N, Schreiber R, Kunzelmann K.
Cl- channels in apoptosis.
Eur Biophys J.
Wetzl V, Schinner E, Kees F, Hofmann F, Faerber L, Schlossmann J
Involvement of Cyclic Guanosine Monophosphate-Dependent Protein Kinase I in Renal Antifibrotic Effects of Serelaxin.
Frontiers in Pharmacology 2016 Jul 12;7:195.
Castrop H
A role for AT1 receptor-associated proteins in blood pressure regulation
Curr Opin Pharmacol, 21C:43-47, 2015
Forschbach V, Goppelt-Struebe M, Kunzelmann K, Schreiber R, Piedagnel R, Kraus A, Eckardt KU, Buchholz B
Anoctamin 6 is localized in the primary cilium of renal tubular cells and is involved in apoptosis-dependent cyst lumen formation.
Cell Death Dis. 2015 Oct 8;6:e1899
Hammer C1, Wanitchakool P2, Sirianant L2, Papiol S1, Monnheimer M, Faria D, Ousingsawat J, Schramek N, Schmitt C, Margos G, Michel A, Kraiczy P, Pawlita M, Schreiber R, Schulz TF, Fingerle V, Tumani H, Ehrenreich H, Kunzelmann K
A coding variant of ANO10, affecting volume regulation of macrophages, is associated with Borrelia seropositivity
Mol Med. 2015 Feb 23;21:26-37
Klootwijk ED, Reichold M, Unwin RJ, Kleta R, Warth R, Bockenhauer D.
Renal Fanconi syndrome: taking a proximal look at the nephron.
Nephrol Dial Transplant. 2015 Sep;30(9):1456-60.
Kraus A, Schley G, Kunzelmann K, Schreiber R, Peters DJ, Stadler R, Eckardt KU, Buchholz B.
Glucose promotes secretion-dependent renal cyst growth
J Mol Med (Berl). 2016 Jan;94(1):107-17
Kunzelmann K
TMEM16, LRRC8A, bestrophin: chloride channels controlled by Ca(2+) and cell volume
Trends Biochem Sci. 2015 Sep;40(9):535-43
Limmer F, Schinner E, Castrop H, Vitzthum H, Hofmann F, Schlossmann J.
Regulation of the Na+ -K+ -2Cl- cotransporter (NKCC2) by cGMP / cGKI after furosemide administration.
FEBS J. 2015 282(19):3786-98.
Liu G, Liu G, Chen H, Borst O, Gawaz M, Vortkamp A, Schreiber R, Kunzelmann K, Lang F.
Involvement of Ca2+ Activated Cl- Channel Ano6 in Platelet Activation and Apoptosis
Cell Physiol Biochem. 2015;37(5):1934-44
Mederle K, Meurer M, Castrop H, Höcherl K.
Inhibition of COX-1 attenuates the formation of thromboxane A2 and ameliorates the acute decrease in glomerular filtration rate in endotoxemic mice
Am J Physiol Renal Physiol, epub ahead of print, 2015
Milenkovic A, Brandl C, Milenkovic VM, Jendryke T, Sirianant L, Wanitchakool P, Zimmermann S, Reiff CM, Horling F, Schrewe H, Schreiber R, Kunzelmann K, Wetzel CH, Weber BH.
Bestrophin 1 is indispensable for volume regulation in human retinal pigment epithelium cells
Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2630-9
Ousingsawat J, Wanitchakool P, Kmit A, Romao AM, Jantarajit W, Schreiber R, Kunzelmann K
Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages
Nat Commun. 2015 Feb 5;6:6245. doi: 10.1038/ncomms7245.
Ousingsawat J, Wanitchakool P, Schreiber R, Wuelling M, Vortkamp A, Kunzelmann K
Anoctamin 6 controls bone mineralization by activating the calcium transporter NCX1
J Biol Chem. 2015 Mar 6;290(10):6270-80
Schießl IM, Castrop H.
Regulation of NKCC2 splicing and phosphorylation.
Curr Opin Nephrol Hypertens, epub ahead of print, 2015
Schießl IM, Hammer A, Kattler V, Gess B, Theilig F, Witzgall R, Castrop H.
Intravital Imaging Reveals Angiotensin II-Induced Transcytosis of Albumin by Podocytes.
J Am Soc Nephrol, Epub ahead of print, 2015
Schießl IM, Kattler V, Castrop H
In Vivo Visualization of the Anti-albuminuric Effects of the Angiotensin Converting Enzyme Inhibitor Enalapril
J Pharmacol Exp Ther, epub ahead of print, 2015
[Pubmed] [Editorial]
Schinner E, Wetzl V, Schlossmann J.
Cyclic nucleotide signalling in kidney fibrosis.
Int J Mol Sci. 2015 16(2):2320-51
Schweda F
Salt feedback on the renin-angiotensin-aldosterone system.
Pflugers Arch. 2015 Mar;467(3):565-76.
Sirianant L, Ousingsawat J, Wanitchakool P, Schreiber R, Kunzelmann K
Cellular volume regulation by anoctamin 6: Ca2+, phospholipase A2 and osmosensing.
Pflugers Arch. 2016 Feb;468(2):335-49
Stasch JP, Schlossmann J, Hocher B.
Renal effects of soluble guanylate cyclase stimulators and activators: a review of the preclinical evidence.
Curr Opin Pharmacol. 2015 Apr;21:95-104
Wolfertstetter S, Reinders J, Schwede F, Ruth P, Schinner E, Schlossmann J.
Interaction of cCMP with the cGK, cAK and MAPK Kinases in Murine Tissues.
PLoS One. 2015 May 15;10(5):e0126057.
Castrop H, Schießl IM
Physiology and Pathophysiology of the Renal Na/K/2Cl Cotransporter NKCC2
Am J Physiol Renal Physiol, epub ahead of print
Castrop H.
Reply to “Letter to the editor: ‘Quantifying albumin permeability with multiphoton microscopy: why the difference?’"
Am J Physiol Renal Physiol, F1101-F1103, 2014
[Pubmed] [Editorial]
Castrop H.
Blunted Renal Autoregulation during High Salt Intake: Advantageous or Deleterious?
Am J Physiol Renal Physiol, 2014
Demerath T, Staffel J, Schreiber A, Valletta D, Schweda F
Natriuretic peptides buffer renin-dependent hypertension
Am J Physiol Renal Physiol. 2014 Jun 15;306(12):F1489-98
Edwards A, Castrop H, Laghmani K, Vallon V, Layton AT.
Effects of NKCC2 isoform regulation and NaCl transport in the thick ascending limb and macula densa cells: a modeling study.
Am J Physiol Renal Physiol, epub ahead of print, 2014
Faria D, Rock JR, Romao AM, Schweda F, Bandulik S, Witzgall R, Schlatter E, Heitzmann D, Pavenstädt H, Herrmann E, Kunzelmann K, Schreiber R
The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function
Kidney Int. 2014 Jun;85(6):1369-81
Gerl M, Kurt B, Kurtz A, Wagner C.
Connexin 43 is not essential for the control of renin synthesis and secretion.
Pflugers Arch. 2014 May;466(5):1003-9.
Gerl M, Vöckl J, Kurt B, van Veen TA, Kurtz A, Wagner C.
Inducible deletion of connexin 40 in adult mice causes hypertension and disrupts pressure control of renin secretion.
Kidney Int. 2014 Sep 17. doi: 10.1038/ki.2014.303. [Epub ahead of print]
Klootwijk ED, Reichold M, Helip-Wooley A, Tolaymat A, Broeker C, Robinette SL, Reinders J, Peindl D, Renner K, Eberhart K, Assmann N, Oefner PJ, Dettmer K, Sterner C, Schroeder J, Zorger N, Witzgall R, Reinhold SW, Stanescu HC, Bockenhauer D, Jaureguiberry G, Courtneidge H, Hall AM, Wijeyesekera AD, Holmes E, Nicholson JK, O'Brien K, Bernardini I, Krasnewich DM, Arcos-Burgos M, Izumi Y, Nonoguchi H, Jia Y, Reddy JK, Ilyas M, Unwin RJ, Gahl WA, Warth R, Kleta R.
Mistargeting of peroxisomal EHHADH and inherited renal Fanconi's syndrome.
N Engl J Med. 2014 Jan 9;370(2):129-38.
Kunzelmann K, Schreiber R
Chloride secretion, anoctamin 1 and Ca(2+) signaling
Channels (Austin). 2014 Sep 3;8(5):387-8
Kurt B, Gerl K, Karger C, Schwarzensteiner I, Kurtz A.
Chronic Hypoxia-Inducible Transcription Factor-2 Activation Stably Transforms Juxtaglomerular Renin Cells into Fibroblast-Like Cells In Vivo.
J Am Soc Nephrol. 2014 Jul 28. pii: ASN.2013111152. [Epub ahead of print]
Kurt B, Karger C, Wagner C, Kurtz A.
Control of renin secretion from kidneys with renin cell hyperplasia.
Am J Physiol Renal Physiol. 2014 Feb 1;306(3):F327-32. .
Machura K, Neubauer B, Müller H, Tauber P, Kurtz A, Kurtz L.
Connexin 40 is dispensable for vascular renin cell recruitment but is indispensable for vascular baroreceptor control of renin secretion.
Pflugers Arch. 2014 Sep 23. [Epub ahead of print]
Neubauer B, Machura K, Rupp V, Tallquist MD, Betsholtz C, Sequeira-Lopez ML, Ariel Gomez R, Wagner C.
Development of renal renin-expressing cells does not involve PDGF-B-PDGFR-β signaling.
Physiol Rep. 2013 Oct;1(5):e00132.
Patrucco E, Domes K, Sbroggió M, Blaich A, Schlossmann J, Desch M, Rybalkin SD, Beavo JA, Lukowski R, Hofmann F
Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis.
Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12925-9
Reichold M, Warth R
Funktionen und klinische Bedeutung des proximalen Tubulus
Der Nephrologe. 2014; DOI 10.1007/s11560-013-0846-9.
Schramm A, Schinner E, Huettner JP, Kees F, Tauber P, Hofmann F, Schlossmann J
Function of cGMP-dependent Protein kinase II in volume load-induced diuresis
Pflugers Arch. 2014 Oct;466(10):2009-18
Schreiber R, Faria D, Skryabin BV, Wanitchakool P, Rock JR, Kunzelmann K
Anoctamins support calcium-dependent chloride secretion by facilitating calcium signaling in adult mouse intestine.
Pflugers Arch. 2015 Jun;467(6):1203-13
Schurek EM1, Völker LA, Tax J, Lamkemeyer T, Rinschen MM, Ungrue D, Kratz JE 3rd, Sirianant L, Kunzelmann K, Chalfie M, Schermer B, Benzing T, Höhne M.
A disease-causing mutation illuminates the protein membrane topology of the kidney-expressed prohibitin homology (PHB) domain protein podocin.
J Biol Chem. 2014 Apr 18;289(16):11262-71
Sirianant L, Ousingsawat J, Tian Y, Schreiber R, Kunzelmann K
TMC8 (EVER2) attenuates intracellular signaling by Zn2+ and Ca2+ and suppresses activation of Cl- currents.
Cell Signal. 2014 Dec;26(12):2826-33
Tinning AR, Jensen BL, Schweda F, Machura K, Hansen PB, Stubbe J, Gramsbergen JB, Madsen K
The water channel aquaporin-1 contributes to renin cell recruitment during chronic stimulation of renin production
Am J Physiol Renal Physiol. 2014 Oct 22 [Epub ahead of print]
Wanitchakool P, Wolf L, Koehl GE, Sirianant L, Schreiber R, Kulkarni S, Duvvuri U, Kunzelmann K.
Role of anoctamins in cancer and apoptosis
Philos Trans R Soc Lond B Biol Sci. 2014 Feb 3;369(1638):20130096
Almaça J, Faria D, Sousa M, Uliyakina I, Conrad C, Sirianant L, Clarke LA, Martins JP, Santos M, Heriché JK, Huber W, Schreiber R, Pepperkok R, Kunzelmann K, Amaral MD.
High-content siRNA screen reveals global ENaC regulators and potential cystic fibrosis therapy targets.
Cell. 2013 Sep 12;154(6):1390-400
Bandulik S, Tauber P, Penton D, Schweda F, Tegtmeier I, Sterner C, Lalli E, Lesage F, Hartmann M, Barhanin J, Warth R
Severe hyperaldosteronism in neonatal task3 potassium channel knockout mice is associated with activation of the intraadrenal Renin-Angiotensin system
Endocrinology. 2013 Aug;154(8):2712-22
Barro-Soria R, Stindl J, Müller C, Foeckler R, Todorov V, Castrop H, Strauß O
Angiotensin-2-mediated Ca2+ signaling in the retinal pigment epithelium: role of angiotensin-receptor-associated-protein and TRPV2 channel.
PLoS One. 2012;7(11):e49624
Braeunig JH, Schweda F, Han PL, Seifert R
Similarly Potent Inhibition of Adenylyl Cyclase by P-Site Inhibitors in Hearts from Wild Type and AC5 Knockout Mice
PLoS One. 2013 Jul 1;8(7)
Buchholz B, Faria D, Schley G, Schreiber R, Eckardt KU, Kunzelmann K.
Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells.
Kidney Int. 2014 May;85(5):1058-67
Buchholz B1, Schley G, Faria D, Kroening S, Willam C, Schreiber R, Klanke B, Burzlaff N, Jantsch J, Kunzelmann K, Eckardt KU.
Hypoxia-Inducible Factor-1α Causes Renal Cyst Expansion through Calcium-Activated Chloride Secretion
J Am Soc Nephrol. 2014 Mar;25(3):465-74
Castrop H, Kurtz A, Schweda F
A special issue on the renin-angiotensin system.
Pflugers Arch. 2013 Jan;465(1):1
Chen W, Oberwinkler H, Werner F, Gaßner B, Nakagawa H, Feil R, Hofmann F, Schlossmann J, Dietrich A, Gudermann T, Nishida M, Del Galdo S, Wieland T, Kuhn M
ANP-mediated inhibition of microcirculatory endothelial Ca2+ and permeability response to histamine involves cGMP-dependent protein kinase I and TRPC6 channels.
Arteriosclerosis, Thrombosis, and Vascular Biology 2013; 33:2121-2129
Hoffmann U, Bergler T, Jung B, Steege A, Pace C, Rümmele P, Reinhold S, Krüger B, Krämer BK, BANAS B
Comprehensive morphometric analysis of mononuclear cell infiltration during experimental renal allograft rejection
Transpl Immunol. 28(1):24-31, 2013
Karger C, Kurtz F, Steppan D, Schwarzensteiner I, Machura K, Angel P, Banas B, Risteli J, Kurtz A.
Procollagen I expressing renin cell precursors.
Am J Physiol Renal Physiol. 2013 Jun 12. [Epub ahead of print]
Kmit A, van Kruchten R, Ousingsawat J, Mattheij NJ, Senden-Gijsbers B, Heemskerk JW, Schreiber R, Bevers EM, Kunzelmann K.
Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents
Cell Death Dis. 2013 Apr 25;4:e611
Kuldo JM, Asgeirsdóttir SA, Zwiers PJ, Bellu AR, Rots MG, Schalk JA, Ogawara KI, Trautwein C, BANAS B, Haisma HJ, Molema G, Kamps JA
Targeted adenovirus mediated inhibition of NF-κB-dependent inflammatory gene expression in endothelial cells in vitro and in vivo
J Control Release. 166(1):57-65, 2013
Kunzelmann K, Mehta A.
CFTR: a hub for kinases and cross-talk of cAMP and Ca2+
FEBS J. 2013 Sep;280(18):4417-29
Kunzelmann K, Nilius B, Owsianik G, Schreiber R, Ousingsawat J, Sirianant L, Wanitchakool P, Bevers EM, Heemskerk JW.
Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase?
Pflugers Arch. 2014 Mar;466(3):407-14
Kurt B, Paliege A, Willam C, Schwarzensteiner I, Schucht K, Neymeyer H, Sequeira-Lopez ML, Bachmann S, Gomez RA, Eckardt KU, Kurtz A
Deletion of von Hippel-Lindau Protein Converts Renin-Producing Cells into Erythropoietin-Producing Cells
J Am Soc Nephrol. 2013;24(3):433-44
Machura K, Iankilevitch E, Neubauer B, Theuring F, Kurtz A
The aldo-keto reductase AKR1B7 coexpresses with renin without influencing renin production and secretion.
Am J Physiol Renal Physiol.2013;304(5):F578-84
Mederle K, Mutig K, Paliege A, Carota I, Bachmann S, Castrop H, Oppermann M
Loss of WNK3 is Compensated for by the WNK1/SPAK Axis in the Kidney of the Mouse
Am J Physiol Renal Physiol, epub ahead of print, 10.1152/ajprenal.00288.2012
Mederle K, Schweda F, Kattler V, Doblinger E, Miyata K, Hocherl K, Oike Y, Castrop H.
The angiotensin II AT1 receptor-associated protein Arap1 is involved in sepsis-induced hypotension.
Crit Care, 17(4), R130, 2013
[Pubmed] [Editorial]
Neubauer B, Machura K, Kettl R, Lopez ML, Friebe A, Kurtz A
Endothelium-derived nitric oxide supports Renin cell recruitment through the nitric oxide-sensitive guanylate cyclase pathway
Hypertension. 2013 Feb;61(2):400-7
[Pubmed] [Editorial]
Oppermann M, Carota I, Schießl IM, Eisner C, Castrop H, Schnermann JB.
Direct assessment of tubuloglomerular feedback responsiveness in connexin 40-deficient mice.
Am J Physiol Renal Physiol, 2013
Rahmati N, Kunzelmann K, Xu J, Barone S, Sirianant L, De Zeeuw CI, Soleimani M.
Slc26a11 is prominently expressed in the brain and functions as a chloride channel: expression in Purkinje cells and stimulation of V H+-ATPase
Pflugers Arch. 2013 Nov;465(11):1583-97
Raspé C, Höcherl K, Rath S, Sauvant C, Bucher M.
NF-kB-mediated inverse regulation of fractalkine and CX3CR1 during CLP-induced sepsis.
Cytokine. 2013 Jan;61(1):97-103.
Reich, B., Schmidbauer, K., Rodriguez Gomez, M., Hermann, F., Göbel, N., Brühl, H., Ketelsen, I., Talke, Y. and Mack, M.
Fibrocytes develop outside the kidney but contribute to renal fibrosis in a mouse model.
Kidney Int. 84:78-89, 2013
Reinhold SW, Scherl T, Stölcker B, Bergler T, Hoffmann U, Weingart C, Banas MC, Kollins D, Kammerl MC, Krüger B, Kaess B, Krämer BK, BANAS B
Lipoxygenase Products in the Urine Correlate with Renal Function and Body Temperature but not with Acute Transplant Rejection
Lipids. 48(2):167-75, 2013
Rodriguez Gomez, M, Talke, Y, Hofmann, C, Ketelsen, I, Hermann, F, Reich, B, Goebel, N, Schmidbauer, K, Dunger, N, Brühl, H, Renner, K, Syed, S-N and Mack, M.
Basophils control T cell Responses and limit Disease Activity in Experimental Murine Colitis.
Mucosal Immunol, doi: 10.1038/mi.2013.38, 2013
Salb K, Schlossmann J
Methods for identification of cGKI substrates.
Methods in Molecular Biology 2013; 1020:147-162
Schießl IM, Bardehle S, Castrop H
Superficial nephrons in BALB/c and C57BL/6 mice facilitate in vivo multiphoton microscopy of the kidney.
PLoS One. 2013;8(1):e52499
Schießl IM, Castrop H.
Angiotensin II AT2 receptor activation attenuates AT1 receptor-induced increases in the glomerular filtration of albumin – a multiphoton microscopy study
Am J Physiol Renal Physiol, 2013
[Pubmed] [Editorial]
Schießl IM, Rosenauer A, Kattler V, Minuth W, Oppermann M, Castrop H.
Dietary Salt Intake Modulates Differential Splicing of the Na/K/2Cl Cotransporter NKCC2
Am J Physiol Renal Physiol, 2013
Schinner E, Schramm A, Kees F, Hofmann F, Schlossmann J
Suppression of kidney fibrosis by cGMP-dependent protein kinase Ialpha
Kidney International 2013; 84:1198-1206
Schlossmann J
Editorial of the special issue: Signalling Molecules and Signal Transduction in Cells
International Journal of Molecular Sciences 2013; 14:11438-11443
Schmid J, Oelbe M, Saftig P, Schwake M, Schweda F
Parallel regulation of renin and lysosomal integral membrane protein 2 in renin-producing cells: further evidence for a lysosomal nature of renin secretory vesicles
Pflugers Arch. 2013 Jun;465(6):895-905
Schmidt K, Ripper M, Tegtmeier I, Humberg E, Sterner C, Reichold M, Warth R, Bandulik S.
Dynamics of renal electrolyte excretion in growing mice.
Nephron Physiol. 2013 Nov 26;124(3-4):7-13.
Schnermann J, Castrop H
Function of the Juxtaglomerular Apparatus: Control of Glomerular Hemodynamics and Renin Secretion
Seldin and Giebisch’s The Kidney, 5th Ed., Elsevier, 2013
Schreiber, R
Wasserresorption in der Niere
Der Nephrologe 2013, Volume 8, Issue 4, pp 344-347
Servidoni MF, Sousa M, Vinagre AM, Cardoso SR, Ribeiro MA, Meirelles LR, de Carvalho RB, Kunzelmann K, Ribeiro AF, Ribeiro JD, Amaral MD.
Rectal forceps biopsy procedure in cystic fibrosis: technical aspects and patients perspective for clinical trials feasibility
BMC Gastroenterol. 2013 May 20;13(1):91
Steppan D, Zügner A, Rachel R, Kurtz A
Structural analysis suggests that renin is released by compound exocytosis
Kidney Int. 2013 Feb;83(2):233-41
Tian Y, Schreiber R, Wanitchakool P, Kongsuphol P, Sousa M, Uliyakina I, Palma M, Faria D, Traynor-Kaplan AE, Fragata JI, Amaral MD, Kunzelmann K.
Control of TMEM16A by INO-4995 and other inositolphosphates
Br J Pharmacol. 2013 Jan;168(1):253-65
Tosoni K, Stobbart M, Cassidy DM, Venerando A, Pagano MA, Luz S, Amaral MD, Kunzelmann K, Pinna LA, Farinha CM, Mehta A.
CFTR mutations altering CFTR fragmentation
Biochem J. 2013 Jan 1;449(1):295-305
Wagner C, Kurtz A
Distribution and functional relevance of connexins in renin-producing cells
Pflugers Arch. 2013 Jan;465(1):71-7
Weiglmeier PR, Berkner H, Seebahn A, Vogel N, Schreiber R, Wöhrl BM, Schwarzinger S, Rösch P
Prosequence switching: An effective strategy to produce biologically active E. coli heat-stable enterotoxin STh.
J Biomol Struct Dyn. 2013 Aug 22. [Epub ahead of print]
Wolfertstetter S, Huettner J, Schlossmann J
cGMP-Dependent Protein Kinase Inhibitors in Health and Disease.
Pharmaceuticals 2013; 6:269-286
Asgeirsdóttir SA, van Solingen C, Kurniati NF, Zwiers PJ, Heeringa P, van Meurs M, Satchell SC, Saleem MA, Mathieson PW, BANAS B, Kamps JA, Rabelink TJ, van Zonneveld AJ, Molema G
MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation
Am J Physiol Renal Physiol. 302(12):F1630-9, 2012
Bergler T, Hoffmann U, Bergler E, Jung B, Banas MC, Reinhold SW, Krämer BK, BANAS B
Toll-Like Receptor 4 in Experimental Kidney Transplantation: Early Mediator of Endogenous Danger Signals
Nephron Exp Nephrol. 121(3-4):e59-e70, 2012
Bergler T, Resch M, Reinhold SW, Birner C, Jungbauer CG, Griese DP, Schmid P, BANAS B, Endemann D.
Cyclosporine a impairs norepinephrine-induced vascular contractility
Kidney Blood Press Res. 35(6):655-62,2012
Birner C, Ulucan C, Bratfisch M, Götz T, Dietl A, Schweda F, Riegger GA, Luchner A
Antihypertrophic effects of combined inhibition of the renin-angiotensin system (RAS) and neutral endopeptidase (NEP) in progressive, tachycardia-induced experimental heart failure
Naunyn Schmiedebergs Arch Pharmacol. 2012 Nov;385(11):1117-25
Castrop H
Angiotensin receptor-associated proteins: local modulators of the renin-angiotensin system.
Pflugers Arch
Chatelain FC, Bichet D, Douguet D, Feliciangeli S, Bendahhou S, Reichold M, Warth R, Barhanin J, Lesage F.
TWIK1, a unique background channel with variable ion selectivity.
Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5499-504.
Doblinger E, Höcherl K, Mederle K, Kattler V, Walter S, Hansen PB, Jensen BL, Castrop H
Angiotensin AT1 Receptor-associated protein Arap1 in the Kidney Vasculature is Suppressed by Angiotensin II.
Am J Physiol Renal Physiol. 2012 May 15;302(10):F1313-24.
Duvvuri U, Shiwarski DJ, Xiao D, Bertrand C, Huang X, Edinger RS, Rock JR, Harfe BD, Henson BJ, Kunzelmann K, Schreiber R, Seethala RS, Egloff AM, Chen X, Lui VW, Grandis JR, Gollin SM.
TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression
Cancer Res. 2012 Jul 1;72(13):3270-81
Faria D, Lentze N, Almaça J, Luz S, Alessio L, Tian Y, Martins JP, Cruz P, Schreiber R, Rezwan M, Farinha CM, Auerbach D, Amaral MD, Kunzelmann K
Regulation of ENaC biogenesis by the stress response protein SERP1
Pflugers Arch. 2012 Jun;463(6):819-27
Jaumann M, Dettling J, Gubelt M, Zimmermann U, Gerling A, Paquet-Durand F, Feil S, Wolpert S, Franz C, Varakina K, Xiong H, Brandt N, Kuhn S, Geisler H-S, Rohbock K, Ruth P, Schlossmann J, Hütter J, Sandner P, Feil R, Engel J, Knipper M, Rüttiger L
cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function.
Nature Medicine 2012; 18:252-259
Jobs A, Schmidt K, Schmidt VJ, Lübkemeier I, van Veen TA, Kurtz A, Willecke K, de Wit C
Defective Cx40 maintains Cx37 expression but intact Cx40 is crucial for conducted dilations irrespective of hypertension
Hypertension. 2012 Dec;60(6):1422-9
Kunzelmann K, Schreiber R
Airway epithelial cells--hyperabsorption in CF?
Int J Biochem Cell Biol. 2012 Aug;44(8):1232-5
Kunzelmann K, Schreiber R, Kmit A, Jantarajit W, Martins JR, Faria D,Kongsuphol P, Ousingsawat J, Tian Y
Expression and function of epithelial anoctamins
Exp Physiol. 2012 Feb;97(2):184-92
Kunzelmann K, Tian Y, Martins JR, Faria D, Kongsuphol P, Ousingsawat J, Wolf L, Schreiber R
Airway epithelial cells--functional links between CFTR and anoctamin dependent Cl- secretion
Int J Biochem Cell Biol. 2012 Nov;44(11):1897-900
Kurtz A
Control of renin synthesis and secretion
Am J Hypertens. 2012 Aug;25(8):839-47
Kurtz A
Renal connexins and blood pressure
Biochim Biophys Acta. 2012 Aug;1818(8):1903-8
Luo C, Gangadharan V, Bali KK, Cie RG, Agarwal N, Kurejova M, Tappe-Theodor A, Tegeder I, Feil S, Lewin G, Polgar E, Todd AJ, Schlossmann J, Hofmann F, Liu DL, Hu SJ, Feil R, Kuner T, Kuner R
Presynaptically localized cyclic GMP-dependent Protein Kinase 1 is a key determinant os spinal potentiation and pain hypersensitivity.
PLOS Biology 2012; 10(3):e1001283.Epub
Machura K, Neubauer B, Steppan D, Kettl R, Groβ A, Kurtz A
Role of blood pressure in mediating the influence of salt intake on renin expression in the kidney.
Am J Physiol Renal Physiol. 2012 May 15;302(10):F1278-85
Mack, M., Niedermeier, M. and Reich, B.
Immunregulation of Fibrocyte Differentiation. Chapter 5 in "Fibrocytes in Health and Disease".
World Scientific Publishing: 53-72, 2012
Majer, O., Bourgeois, C., Zwolanek, F., Lassnig, C., Kerjaschki, D., Mack, M., Muller, M. and Kuchler, K.
Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections.
PLoS Pathog. 8: e1002811, 2012
Oeggerli M, Tian Y, Ruiz C, Wijker B, Sauter G, Obermann E, Güth U, Zlobec I, Sausbier M, Kunzelmann K, Bubendorf L.
Role of KCNMA1 in breast cancer
PLoS One. 2012;7(8):e41664
Ousingsawat J, Schreiber R, Kunzelmann K
Differential contribution of SLC26A9 to Cl(-) conductance in polarized and non-polarized epithelial cells
J Cell Physiol. 2012 Jun;227(6):2323-9
Penton D, Bandulik S, Schweda F, Haubs S, Tauber P, Reichold M, Cong LD, El Wakil A, Budde T, Lesage F, Lalli E, Zennaro MC, Warth R, Barhanin J
Task3 potassium channel gene invalidation causes low renin and salt-sensitive arterial hypertension
Endocrinology. 2012 Oct;153(10):4740-8
Reinhold SW, Krüger B, Barner C, Zoicas F, Kammerl MC, Hoffmann U, Bergler T, BANAS B, Krämer BK
Nephron-specific expression of components of the renin-angiotensin-aldosterone system in the mouse kidney
J Renin Angiotensin Aldosterone Syst. 13(1):46-55, 2012
Reinhold SW, Straub RH, Krüger B, Kaess B, Bergler T, Weingart C, Banas MC, Krämer BK, BANAS B
Elevated urinary sVCAM-1, IL6, sIL6R and TNFR1 concentrations indicate acute kidney transplant rejection in the first 2 weeks after transplantation
Cytokine. 57(3):379-88, 2012
Ruiz C, Martins JR, Rudin F, Schneider S, Dietsche T, Fischer CA, Tornillo L,Terracciano LM, Schreiber R, Bubendorf L, Kunzelmann K
Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis
PLoS One. 2012;7(8):e43265
Salb K, Schinner E, Schlossmann J
Identification of cGMP-Kinase complexes by affinity chromatography.
INTECH Chapter in "Affinity Chromatography" 2012; 255-272
Schlossmann J, Schinner E
cGMP becomes a drug target.
Naunyn Schmiedeberg`Archives of Pharmacology 2012; 385,3:243-252
Schreiber A, Shulhevich Y, Geraci S, Hesser J, Stsepankou D, Neudecker S, Koenig S, Heinrich R, Hoecklin F, Pill J, Friedemann J, Schweda F, Gretz N, Schock-Kusch D.
Transcutaneous measurement of renal function in conscious mice.
Am J Physiol Renal Physiol. 2012 Sep;303(5):F783-8
Schreiber A, Theilig F, Schweda F, Höcherl K.
Acute endotoxemia in mice induces downregulation of megalin and cubilin in the kidney.
Kidney Int. 82:53-59.
Sousa M, Servidoni MF, Vinagre AM, Ramalho AS, Bonadia LC, Felício V, Ribeiro MA, Uliyakina I, Marson FA, Kmit A, Cardoso SR, Ribeiro JD, Bertuzzo CS, Sousa L, Kunzelmann K, Ribeiro AF, Amaral MD.
Measurements of CFTR-mediated Cl- secretion in human rectal biopsies constitute a robust biomarker for Cystic Fibrosis diagnosis and prognosis
PLoS One. 2012;7(10):e47708
Szteyn K, Schmid E, Nurbaeva MK, Yang W, Münzer P, Kunzelmann K, Lang F, Shumilina E
Expression and Functional Significance of the Ca-Activated Cl(-)Channel ANO6 in Dendritic Cells
Cell Physiol Biochem. 2012;30(5):1319-32
Tian Y, Schreiber R, Kunzelmann K.
Anoctamins are a family of Ca2+-activated Cl- channels
J Cell Sci. 2012 Nov 1;125(Pt 21):4991-8
Zigmond, E., Varol, C., Farache, J., Elmaliah, E., Satpathy, A. T., Friedlander, G., Mack, M., Shpigel, N., Boneca, I. G., Murphy, K. M., Shakhar, G., Halpern, Z. and Jung, S.
Ly6C(hi) Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells.
Immunity. 37: 1076-1090, 2012
Aldehni F, Tang T, Madsen K, Plattner M, Schreiber A, Friis UG, Hammond HK, Han PL, Schweda F.
Stimulation of renin secretion by catecholamines is dependent on adenylyl cyclases 5 and 6.
Hypertension. 2011 Mar;57(3):460-8.
Almaça J, Dahimène S, Appel N, Conrad C, Kunzelmann K, Pepperkok R, Amaral MD
Functional genomics assays to study CFTR traffic and ENaC function
Methods Mol Biol. 2011;742:249-64
Bandulik S, Schmidt K, Bockenhauer D, Zdebik AA, Humberg E, Kleta R, Warth R, Reichold M.
The salt-wasting phenotype of EAST syndrome, a disease with multifaceted symptoms linked to the KCNJ10 K(+) channel.
Pflugers Arch. 2011 Jan 11. [Epub ahead of print]
Böckenhauer D, Stanescu H, Bandulik S, Reichold M, Zdebik A, Warth R, Kleta R
EAST-Syndrom: Ein neues Krankheitsbild mit renalem Salzverlust.
Nephrologe 2011; 6:529–536.
Desch M, Hackmayer G, Todorov VT.
Identification of ATF2 as a transcriptional regulator of renin gene.
Biol Chem. 2011 Oct 13. [Epub ahead of print]
Desch M, Harlander S, Neubauer B, Gerl M, Germain S, Castrop H, Todorov VT.
cAMP target sequences enhCRE and CNRE sense low-salt intake to increase human renin gene expression in vivo.
Pflugers Arch, 2011, 461(5):567-77
Ertl C, Lukowski R, Sigl K, Schlossmann J, Hofmann F, Wegener JW
Kinetics of relaxation by cGMP/cGKI signaling in fundus smooth muscle
Eur J Pharmacol. 2011; 670:266-271
Freudenthal B, Kulaveerasingam D, Lingappa L, Shah MA, Brueton L, Wassmer E, Ognjanovic M, Dorison N, Reichold M, Bockenhauer D, Kleta R, Zdebik AA.
KCNJ10 Mutations Disrupt Function in Patients with EAST Syndrome.
Nephron Physiol. 2011 Aug 18;119(3):p40-p48.
Hoffmann U, Bergler T, Rihm M, Pace C, Krüger B, Jung B, Reinhold SW, Farkas S, Rümmele P, Krämer BK, BANAS B
Impact of Toll-like receptor 2 expression in renal allograft rejection
Nephrol Dial Transplant. 26(3):1080-7, 2011
Höcherl K, Gerl M, Schweda F.
Proteinase-activated receptors 1 and 2 exert opposite effects on renal renin release.
Hypertension. 2011 Oct;58(4):611-8.
Kollins D, Stoelcker B, Hoffmann U, Bergler T, Reinhold S, Banas MC, Rümmele P, Farkas S, Krämer BK, BANAS B
FOXP3+ regulatory T-cells in renal allografts: correlation with long-term graft function and acute rejection
Clin Nephrol. 75(2):91-100, 2011
Kongsuphol P, Schreiber R, Kraidith K, Kunzelmann K
CFTR induces extracellular acid sensing in Xenopus oocytes which activates endogenous Ca2+-activated Cl- conductance
Pflugers Arch. 2011 Sep;462(3):479-87
Kunzelmann K
Introduction to section V: assessment of CFTR function.
Methods Mol Biol. 2011;741:407-18
Kunzelmann K, Kongsuphol P, Chootip K, Toledo C, Martins JR, Almaca J, Tian Y, Witzgall R, Ousingsawat J, Schreiber R.
Role of the Ca2+ -activated Cl- channels bestrophin and anoctamin in epithelial cells.
Biol Chem. 2011; 392: 125-34.
Kunzelmann K, Tian Y, Martins JR, Faria D, Kongsuphol P, Ousingsawat J, Thevenod F, Roussa E, Rock J, Schreiber R
Pflugers Arch. 2011 Aug;462(2):195-208
Kurotaki, D., Kon, S., Bae, K., Ito, K., Matsui, Y., Nakayama, Y., Kanayama, M., Kimura, C., Narita, Y., Nishimura, T., Iwabuchi, K., Mack, M., van Rooijen, N., Sakaguchi, S., Uede, T. and Morimoto, J.
CSF-1-dependent red pulp macrophages regulate CD4 T cell responses.
J Immunol. 186: 2229-2237, 2011
Kurt B, Kurtz L, Sequeira-Lopez ML, Gomez RA, Willecke K, Wagner C, Kurtz A
Reciprocal expression of connexin 40 and 45 during phenotypical changes in renin-secreting cells
Am J Physiol Renal Physiol. 2011 Mar;300(3):F743-8
Kurtz A.
Renin release: sites, mechanisms, and control
Annu Rev Physiol. 2011Mar 17;73:377-99
Liu W, Schreck C, Coleman RA, Wade JB, Hernandez Y, Zavilowitz B, Warth R, Kleyman TR, Satlin LM.
Role of NKCC in BK channel-mediated net K+ secretion in the CCD.
Am J Physiol Renal Physiol. 2011 Aug 3. [Epub ahead of print]
London, A., Itskovich, E., Benhar, I., Kalchenko, V., Mack, M., Jung, S. and Schwartz, M.
Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages.
J Exp Med. 208: 23-39, 2011
Luz S, Kongsuphol P, Mendes AI, Romeiras F, Sousa M, Schreiber R, Matos P,Jordan P, Mehta A, Amaral MD, Kunzelmann K, Farinha CM
Contribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking and protein kinase A-induced activity.
Mol Cell Biol. 2011 Nov;31(22):4392-404
Lübkemeier I, Machura K, Kurtz L, Neubauer B, Dobrowolski R, Schweda F, Wagner C, Willecke K, Kurtz A
The connexin 40 A96S mutation causes renin-dependent hypertension
J Am Soc Nephrol. 2011 Jun;22(6):1031-40
[Pubmed] [Editorial]
Martins JR, Faria D, Kongsuphol P, Reisch B, Schreiber R, Kunzelmann K
Anoctamin 6 is an essential component of the outwardly rectifying chloride channel.
Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18168-72
Martins JR, Kongsuphol P, Sammels E, Dahimène S, Aldehni F, Clarke LA,Schreiber R, de Smedt H, Amaral MD, Kunzelmann K
F508del-CFTR increases intracellular Ca(2+) signaling that causes enhanced calcium-dependent Cl(-)conductance in cystic fibrosis.
Biochim Biophys Acta. 2011 Nov;1812(11):1385-92
Ousingsawat J, Kongsuphol P, Schreiber R, Kunzelmann K
CFTR and TMEM16A are separate but functionally related Cl- channels
Cell Physiol Biochem. 2011;28(4):715-24
Ousingsawat J, Mirza M, Tian Y, Roussa E, Schreiber R, Cook DI, Kunzelmann K
Rotavirus toxin NSP4 induces diarrhea by activation of TMEM16A and inhibition of Na+ absorption.
Pflugers Arch. 2011 May;461(5):579-89
Raupach T, Lüthje L, Kögler H, Duve C, Schweda F, Hasenfuss G, Andreas S
Local and systemic effects of angiotensin receptor blockade in an emphysema mouse model
Pulm Pharmacol Ther. 2011 Apr;24(2):215-20
Schinner E, Salb K, Schlossmann J
Signaling via IRAG is essential for NO/cGMP-dependent inhibition of platelet activation
Platelets 2011; 22 (3): 217-227
Schley G, Klanke B, Schödel J, Forstreuter F, Shukla D, Kurtz A, Amann K,Wiesener MS, Rosen S, Eckardt KU, Maxwell PH, Willam C
Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury
J Am Soc Nephrol. 2011 Nov;22(11):2004-15
Schlossmann J, Desch M
IRAG and Novel PKG Targeting in the cardiovascular system.
American Journal of Physiology-Heart and Circulatory Physiology 2011; 301:H672-682
Schweda F, Kurtz A.
Regulation of renin release by local and systemic factors
Rev Physiol Biochem Pharmacol. 2011;161:1-44.
Thompson DA, Feather S, Stanescu HC, Freudenthal B, Zdebik AA, Warth R, Ognjanovic M, Hulton SA, Wassmer E, Van't Hoff W, Russell-Eggitt I, Dobbie A, Sheridan E, Kleta R, Bockenhauer D
Altered electroretinograms in patients with KCNJ10 mutations and EAST syndrome
J Physiol. 2011 Feb 7. [Epub ahead of print]
Tian Y, Kongsuphol P, Hug M, Ousingsawat J, Witzgall R, Schreiber R, Kunzelmann K
Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A.
FASEB J. 2011 Mar;25(3):1058-68
Wenger RH, Kurtz A
Compr Physiol. 2011;1(4):1759-94
Werder A, Mayr M, Schneider G, Oesterle D, Fritsch RM, Seidler B, Schlossmann J, Hofmann F, Schemann M, Allescher HD, Schmid RM, Saur D
Truncated IRAG variants modulate cGMP-mediated inhibition of human colonic smooth muscle cell contraction.
Am J Physiol Cell Physiol. 2011; 301(6):C1445-1457
Barro-Soria R, Aldehni F, Almaça J, Witzgall R, Schreiber R, Kunzelmann K
ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel.
Pflugers Arch. 2010 Feb;459(3):485-97
Baskaran, K., Brunner, K., Munte, C.E., kalbitzer, H.R.
Mapping of protein structural ensembles by chemical shifts.
J Biomol NMR. 2010 Oct;48(2):71-83.
Carota I, Theilig F, Oppermann M, Kongsuphol P, Rosenauer A, Schreiber R, Jensen BL, Walter S, Kunzelmann K, Castrop H.
Localization and functional characterization of the human NKCC2 isoforms.
Acta Physiol (Oxf). 2010 Jul 1;199(3):327-38
Castrop H, Höcherl K, Kurtz A, Schweda F, Todorov V, Wagner C
Physiology of kidney renin
Physiol Rev. 2010, 90(2):607-73
Castrop H, Kurtz A.
Functional evidence confirmed by histological localization: overlapping expression of erythropoietin and HIF-2alpha in interstitial fibroblasts of the renal cortex.
Kidney Int. 2010 Feb;77(4):269-71.
Castrop H.
Genetically modified mice-successes and failures of a widely used technology.
Pflugers Arch. 2010 Mar;459(4):557-67.
Chen L, Kim SM, Eisner C, Oppermann M, Huang Y, Mizel D, Li L, Chen M, Sequeira Lopez ML, Weinstein LS, Gomez RA, Schnermann J, Briggs JP
Stimulation of renin secretion by angiotensin II blockade is Gsalpha-dependent.
J Am Soc Nephrol. 2010 Jun;21(6):986-92
Desch M, Schinner E, Kees F, Hofmann F, Seifert R, Schlossmann J
Cyclic cytidine 3',5'-monophosphate (cCMP) signals via cGMP kinase I.
FEBS Lett. 2010 Sep 24;584(18):3979-3984
Desch M, Schreiber A, Schweda F, Madsen K, Friis UG, Weatherford ET, Sigmund CD, Sequeira Lopez ML, Gomez RA, Todorov VT.
Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-gamma in juxtaglomerular cells.
Hypertension. 2010 Mar;55(3):660-6.
Desch M, Schubert T, Schreiber A, Mayer S, Friedrich B, Artunc F, Todorov VT.
PPAR{gamma}-Dependent Regulation of Adenylate Cyclase 6 Amplifies the Stimulatory Effect of cAMP on Renin Gene Expression.
Mol Endocrinol. 2010 Nov;24(11):2139-51. Epub 2010 Sep 22.
Desch M, Sigl K, Hieke B, Salb K, Kees F, Bernhard D, Jochim A, Spiessberger B, Höcherl K, Feil R, Feil S, Lukowski R, Wegener JW, Hofmann F, Schlossmann J
IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation.
Cardiovasc Res. 2010 Jun 1; 86(3):496-505
Duning K, Rosenbusch D, Schlüter MA, Tian Y, Kunzelmann K, Meyer N, Schulze U, Markoff A, Pavenstädt H, Weide T.
Polycystin-2 activity is controlled by transcriptional coactivator with PDZ binding motif and PALS1-associated tight junction protein.
J Biol Chem. 2010; 285: 33584-8.
Faria D, Dahimène S, Alessio L, Scott-Ward T, Schreiber R, Kunzelmann K, Amaral MD.
Effect of Annexin A5 on CFTR: regulated traffic or scaffolding?
Mol Membr Biol. 2011; 28: 14-29.
Gestreau C, Heitzmann D, Thomas J, Dubreuil V, Bandulik S, Reichold M, Bendahhou S, Pierson P, Sterner C, Peyronnet-Roux J, Benfriha C, Tegtmeier I, Ehnes H, Georgieff M, Lesage F, Brunet JF, Goridis C, Warth R, Barhanin J.
Task2 potassium channels set central respiratory CO2 and O2 sensitivity.
PNAS 2010;107(5):2325-30.
Göttle M, Dove S, Kees F, Schlossmann J, Geduhn J, König B, Shen Y, Tang WJ, Kaever V, Seifert R
Cytidylyl and uridylyl cyclase activity of bacillus anthracis edema factor and Bordetella pertussis CyaA.
Biochemistry 2010 Jul 6; 49(26):5494-5503
Hausmann R, Kuppe C, Egger H, Schweda F, Knecht V, Elger M, Menzel S, Somers D, Braun G, Fuss A, Uhlig S, Kriz W, Tanner G, Floege J, Moeller MJ.
Electrical forces determine glomerular permeability.
J Am Soc Nephrol. 2010 Dec;21(12):2053-8
Hoffmann U, Bergler T, Segerer S, Rümmele P, Krüger B, Banas MC, Reinhold S, BANAS B, Krämer BK.
Impact of chemokine receptor CX3CR1 in human renal allograft rejection
Transpl Immunol. 23(4):204-8, 2010
Höcherl K, Schmidt C, Kurt B, Bucher M.
Inhibition of NF-{kappa}B ameliorates sepsis-induced downregulation of aquaporin-2 / V2 receptor expression and acute renal failure in vivo.
Am J Physiol Renal Physiol. 2010, 298(1):F196-204.
Koehl GE, Spitzner M, Ousingsawat J, Schreiber R, Geissler EK, Kunzelmann K.
Rapamycin inhibits oncogenic intestinal ion channels and neoplasia in APC(Min/+) mice.
Oncogene. 2010; 29: 1553-60.
Kongsuphol P, Cassidy D, Romeiras F, Schreiber R, Mehta A, Kunzelmann K.
Metformin treatment of diabetes mellitus increases the risk for pancreatitis in patients bearing the CFTR-mutation S573C.
Cell Physiol Biochem. 2010; 25: 389-96.
Kunzelmann K and Thews O.
Lungenatmung in RF Schmidt, F Lang, M Heckmann: Physiologie des Menschen
Springer Berlin/Heidelberg 30: 756-786
Kurtz A
Salt intake and the nitric oxide-cyclic AMP signaling pathway in renin secreting cells
Am J Hypertens. 2010 Nov;23(11):1157
Kurtz L, Madsen K, Kurt B, Jensen BL, Walter S, Banas B, Wagner C, Kurtz A
High-level connexin expression in the human juxtaglomerular apparatus
Nephron Physiol. 2010;116:1-8
Malloni, W. M., De Sanctis, S., Tomé, A. M., Lang, E. W., Munte, C. E., Neidig, K.-P. and, Kalbitzer, H. R.
Automated solvent artifact removal and base plane correction of multidimensional NMR protein spectra by AUREMOL-SSA.
J Biomol NMR. 2010 Jun;47(2):101-11.
Mathar I, Vennekens R, Meissner M, Kees F, Van der Mieren G, Camacho Londoño JE, Uhl S, Voets T, Hummel B, van den Bergh A, Herijgers P, Nilius B, Flockerzi V, Schweda F, Freichel M
Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice.
J Clin Invest. 2010 Sep;120(9):3267-79
Milenkovic VM, Brockmann M, Meyer C, Desch M, Schweda F, Kurtz A, Todorov VT, Strauss O.
Regulation of the renin expression in the retinal pigment epithelium by systemic stimuli.
Am J Physiol Renal Physiol. 2010 Aug;299(2):F396-403.
Movahedi, K., Laoui, D., Gysemans, C., Baeten, M., Stange, G., Van den Bossche, J., Mack, M., Pipeleers, D., In't Veld, P., De Baetselier, P. and Van Ginderachter, J. A.
Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes.
Cancer Res. 70: 5728-5739, 2010
Oppermann M, Gess B, Schweda F, Castrop H.
Atrap Deficiency Increases Arterial Blood Pressure and Plasma Volume.
J Am Soc Nephrol. 2010 Jan 21. [Epub ahead of print]
Pohl M, Kaminski H, Castrop H, Bader M, Himmerkus N, Bleich M, Bachmann S, Theilig F
Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron.
J Biol Chem, 2010 [Epub ahead of print]
Preston P, Wartosch L, Günzel D, Fromm M, Kongsuphol P, Ousingsawat J, Kunzelmann K, Barhanin J, Warth R, Jentsch TJ.
Disruption of the K+ channel beta-subunit KCNE3 reveals an important role in intestinal and tracheal Cl- transport.
J Biol Chem. 2010; 285: 7165-75.
Reichold M, Zdebik AA, Lieberer E, Rapedius M, Schmidt K, Bandulik S, Sterner C, Tegtmeier I, Penton D, Baukrowitz T, Hulton SA, Witzgall R, Ben-Zeev B, Howie AJ, Kleta R, Bockenhauer D, Warth R.
KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function.
Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14490-5.
Rodriguez Gomez, M., Talke, Y., Goebel, N., Hermann, F., Reich, B. and Mack, M.
Basophils support the survival of plasma cells in mice.
J Immunol. 185: 7180-7185, 2010
Schmidt C, Höcherl K, Kurt B, Moritz S, Kurtz A, Bucher M.
Blockade of multiple but not single cytokines abrogates downregulation of angiotensin II type-I receptors and anticipates septic shock.
Cytokine. 2010, 49(1):30-8.
Schödel J, Bohr D, Klanke B, Schley G, Schlötzer-Schrehardt U, Warnecke C, Kurtz A, Amann K, Eckardt KU, Willam C
Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells
Kidney Int. 2010 Nov;78(9):857-67
Schödel J, Bohr D, Klanke B, Schley G, Schlötzer-Schrehardt U, Warnecke C,Kurtz A, Amann K, Eckardt KU, Willam C
Factor inhibiting HIF limits the expression of hypoxia-inducible genes in podocytes and distal tubular cells
Kidney Int. 2010 Nov;78(9):857-67
Schreiber R, Uliyakina I, Kongsuphol P, Warth R, Mirza M, Martins JR, Kunzelmann K.
Expression and function of epithelial anoctamins.
J Biol Chem. 2010; 285: 7838-45.
Skals M, Jensen UB, Ousingsawat J, Kunzelmann K, Leipziger J, Praetorius HA.
Escherichia coli alpha-hemolysin triggers shrinkage of erythrocytes via K(Ca)3.1 and TMEM16A channels with subsequent phosphatidylserine exposure.
J Biol Chem. 2010; 285: 15557-65.
Wagner C, Jobs A, Schweda F, Kurtz L, Kurt B, Lopez ML, Gomez RA, van Veen TA,de Wit C, Kurtz A
Selective deletion of Connexin 40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension
Kidney Int. 2010 Oct;78(8):762-8
Aldehni F, Spitzner M, Martins JR, Barro-Soria R, Schreiber R, Kunzelmann K.
Bestrophin 1 promotes epithelial-to-mesenchymal transition of renal collecting duct cells.
J Am Soc Nephrol. 2009, 20: 1556-64.
Almaça J, Kongsuphol P, Hieke B, Ousingsawat J, Viollet B, Schreiber R, Amaral MD, Kunzelmann K.
AMPK controls epithelial Na(+) channels through Nedd4-2 and causes an epithelial phenotype when mutated.
Pflugers Arch. 2009; 458: 713-21.
Almaça J, Tian Y, Aldehni F, Ousingsawat J, Kongsuphol P, Rock JR, Harfe BD, Schreiber R, Kunzelmann K.
TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A.
J Biol Chem. 2009, 16; 284: 28571-8.
Barro Soria R, Spitzner M, Schreiber R, Kunzelmann K.
Bestrophin-1 enables Ca2+-activated Cl- conductance in epithelia.
J Biol Chem. 2009, 284: 29405-12.
Baskaran, K., Kirchhöfer, R., Huber, F., Trenner, J., Brunner, K., Gronwald, W., Neidig, K.-P. and Kalbitzer, H. R.
Chemical Shift Optimization in Multidimensional NMR Spectra by AUREMOL-SHIFTOPT
J Biomol NMR. 2009 Apr;43(4):197-210.
Binder, NB, Niederreiter, B, Hoffmann, O, Stange, R, Pap, T, Stulnig, TM, Mack, M, Erben, RG, Smolen, JS and Redlich, K.
Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis.
Nat Med 2009.
Bockenhauer D, Feather S, Stanescu HC, Bandulik S, Zdebik AA, Reichold M, Tobin J, Lieberer E, Sterner C, Landoure G, Arora R, Sirimanna T, Thompson D, Cross JH, van't Hoff W, Al Masri O, Tullus K, Yeung S, Anikster Y, Klootwijk E, Hubank M, Dillon MJ, Heitzmann D, Arcos-Burgos M, Knepper MA, Dobbie A, Gahl WA, Warth R, Sheridan E, Kleta R.
Epilepsy, ataxia, sensorineural deafness, tubulopathy, and KCNJ10 mutations.
N Engl J Med. 2009 May 7;360(19):1960-70.
[Pubmed] [Editorial]
Brühl, H, Cihak, J, Niedermeier, M, Denzel, A, Rodrigues Gomez, M, Talke, Y, Goebel, N, Plachy, J, Stangassinger, M and Mack, M.
Important role of IL-3 in the early phase of collagen induced arthritis.
Arthritis Rheum 2009. in press.
Cano, C., Brunner, K., Baskaran, K., Elsner, R., Munte, C. E. and Kalbitzer, H. R.
Protein structure calculation with data imputation: the use of substitute restraints.
J Biomol NMR. 2009 Dec;45(4):397-411
Cruickshank, SM, Deschoolmeester, ML, Svensson, M, Howell, G, Bazakou, A, Logunova, L, Little, MC, English, N, Mack, M, Grencis, RK, Else, KJ and Carding, SR.
Rapid dendritic cell mobilization to the large intestinal epithelium is associated with resistance to Trichuris muris infection.
J Immunol 2009. 182: 3055-3062.
Faria D, Schreiber R, Kunzelmann K.
CFTR is activated through stimulation of purinergic P2Y2 receptors.
Pflugers Arch. 2009, 457: 1373-80.
Gadau J, Peters H, Kastner C, Kühn H, Nieminen-Kelhä M, Khadzhynov D, Krämer S, Castrop H, Bachmann S, Theilig F.
Mechanisms of tubular volume retention in immune-mediated glomerulonephritis.
Kidney Int. 2009 Feb 4.
Gao HX, Campbell SR, Burkly LC, Jakubowski A, Jarchum I, BANAS B, Saleem MA, Mathieson PW, Berman JW, Michaelson JS, Putterman C
TNF-like weak inducer of apoptosis (TWEAK) induces inflammatory and proliferative effects in human kidney cells
Cytokine. 46(1):24-35, 2009
Goldwich A, Scholz M, Tamm ER.
Myocilin promotes substrate adhesion, spreading and formation of focal contacts in podocytes and mesangial cells.
Histochem Cell Biol. 2009 Feb;131(2):167-80.
Hoffmann U, Bergler T, Rihm M, Pace C, Krüger B, Rümmele P, Stoelcker B, BANAS B, Männel DN, Krämer BK
Upregulation of TNF receptor type 2 in human and experimental renal allograft rejection
Am J Transplant. 9(4):675-86, 2009
Höcherl K, Schmidt C, Bucher M.
COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the rat renal cortex.
Kidney Int. 2009, 75(4):373-80.
Just A, Kurtz L , de Wit C, Wagner C , Kurtz A, Arendshorst WJ.
J Am Soc Nephrol. 2009 Jul;20(7):1577-85.
Kalbitzer, H. R., Spoerner, M., Ganser, P., Hosza, C. and Kremer, W.
Fundamental link between folding states and functional states of proteins.
J. Am. Chem. Soc., 131, 16714–16719.
Kongsuphol P, Cassidy D, Hieke B, Treharne KJ, Schreiber R, Mehta A, Kunzelmann K.
Mechanistic insight into control of CFTR by AMPK.
J Biol Chem 2009, 284: 5645-5633
Kongsuphol P, Hieke B, Ousingsawat J, Almaca J, Viollet B, Schreiber R, Kunzelmann K.
Regulation of Cl(-) secretion by AMPK in vivo.
Pflugers Arch. 2009 Mar;457(5):1071-8
Kunzelmann K and Mall M.
Cystic Fibrosis: Encyclopedic Reference of Molecular Mechanisms of Disease
Springer, Berlin 1: 1224, 2009
Kunzelmann K, Kongsuphol P, Aldehni F, Tian Y, Ousingsawat J, Warth R, Schreiber R.
Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions.
Cell Calcium. 2009; 46: 233-41.
Kurtz L, Janssen-Bienhold U, Kurtz A, Wagner C.
Connexin expression in Renin-producing cells.
J Am Soc Nephrol. 2009 Mar;20(3):506-12.
Lee WK, Reichold M, Edemir B, Ciarimboli G, Warth R, Koepsell H, Thevenod F.
The organic cation transporters OCT1, 2, and 3 mediate high affinity transport of the mutagenic vital dye ethidium in the kidney proximal tubule.
Am J Physiol Renal Physiol. 2009 Apr 8.
Machnik A, Neuhofer W, Jantsch J, Dahlmann A, Tammela T, Machura K, Park JK, Beck FX, Müller DN, Derer W, Goss J, Ziomber A, Dietsch P, Wagner H, van Rooijen N, Kurtz A, Hilgers KF, Alitalo K, Eckardt KU, Luft FC, Kerjaschki D, Titze J.
Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.
Nat Med. 2009 May;15(5):545-52.
[Pubmed] [Editorial]
Milenkovic VM, Soria RB, Aldehni F, Schreiber R, Kunzelmann K.
Functional assembly and purinergic activation of bestrophins.
Pflugers Arch. 2009; 458: 431-41.
Neubauer B, Machura K, Chen M, Weinstein LS, Oppermann M, Sequeira Lopez ML, Gomez RA, Schnermann JB, Castrop H, Kurtz A, Wagner C.
Am J Physiol Renal Physiol. 2009 Mar 4.
Niedermeier M, Reich B, Rodriguez Gomez M, Denzel A, Schmidbauer K, Göbel N, Talke Y, Schweda F, Mack M
CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes.
Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17892-7
Oppermann M, Qin Y, Lai EY, Eisner C, Li L, Huang YG, Mizel D, Fryc J, Wilcox CS, Briggs JP, Schnermann JB, Castrop H.
Enhanced Tubuloglomerular Feedback (TGF) in Mice with Vascular Over-Expression of A1 Adenosine Receptors (A1AR).
Am J Physiol Renal Physiol. 2009 Sep 9.
Osten L, Kubitza M, Gallagher AR, Kastner J, Olbrich H, de Vries U, Kees F, Lelongt B, Somlo S, Omran H, Witzgall R.
Doxycycline accelerates renal cyst growth and fibrosis in the pcy/pcy mouse model of type 3 nephronophthisis, a form of recessive polycystic kidney disease.
Histochem Cell Biol. 2009 Aug;132(2):199-210.
Ostreicher I, Meissner U, Plank C, Allabauer I, Castrop H, Rascher W, Dötsch J
Altered leptin secretion in hyperinsulinemic mice under hypoxic conditions
Regul Pept, 2009, 153(1-3):25-9
Ousingsawat J, Martins JR, Schreiber R, Rock JR, Harfe BD, Kunzelmann K.
Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport.
J Biol Chem. 2009; 284: 28698-703.
Rascle A, Neumann T, Raschta AS, Neumann A, Heining E, Kastner J, Witzgall R.
The LIM-homeodomain transcription factor LMX1B regulates expression of NF-kappa B target genes.
Exp Cell Res. 2009 Jan 1;315(1):76-96.
Reinhold SW, Uihlein DC, Böger CA, Kloiber S, Frölich K, Bergler T, Banas B, Schweda F, Krämer BK
Renin, endothelial NO synthase and endothelin gene expression in the 2kidney-1clip Goldblatt model of long-term renovascular hypertension
Eur J Med Res. 2009;14:520-5
Rotte A, Bhandaru M, Föller M, Biswas R, Mack AF, Friedrich B, Rexhepaj R, Nasir O, Ackermann TF, Boini KM, Kunzelmann K, Behrens J, Lang F.
APC sensitive gastric acid secretion.
Cell Physiol Biochem. 2009; 23: 133-42.
Schmidt C, Kurt B, Höcherl K, Bucher M.
Inhibition of NF-kappaB activity prevents downregulation of alpha1-adrenergic receptors and circulatory failure during CLP-induced sepsis.
Shock. 2009, 32(3):239-246.
Schödel J, Klanke B, Weidemann A, Buchholz B, Bernhardt W, Bertog M, Amann K, Korbmacher C, Wiesener M, Warnecke C, Kurtz A, Eckardt KU, Willam C.
HIF-prolylhydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury.
Am J Pathol. 2009;174:1663-74.
Schreier, C., Auer, A., Kalbitzer, H. R. and Kremer, W.
NMR Assignments of a 48 kDa Tetramer of the T1 Domain of the mammalian Voltage Gated Potassium Channel Kv1.4.
Biomol NMR Assign. 2009 Dec;3(2):167-70.
Schumann, F. H., Hoffmeister, H., Schmidt, M., Bader, R., Besl, E., Witzgall, R. and Kalbitzer, H. R.
NMR-Assignments of a Cytosolic Domain of the C-Terminus of Polycystin-2.
Biomol NMR Assign. 2009 Jun;3(1):141-4.
Schumann, F., Hoffmeister, H., Bader, R., Schmidt, M., Witzgall, R., and Kalbitzer, H. R.
Ca2+-Dependent Conformational Changes in a C-terminal Cytosolic Domain of Polycystin-2.
J. Biol. Chem. 284, 24372–24383.
Schweda F, Kurtz L, de Wit C, Janssen-Bienhold U, Kurtz A, Wagner C.
Substitution of connexin40 with connexin45 prevents hyperreninemia and attenuates hypertension.
Kidney Int. 2009 Mar;75(5):482-9.
[Pubmed] [Editorial]
Treharne KJ, Xu Z, Chen JH, Best OG, Cassidy DM, Gruenert DC, Hegyi P, Gray MA, Sheppard DN, Kunzelmann K, Mehta A.
Inhibition of protein kinase CK2 closes the CFTR Cl channel, but has no effect on the cystic fibrosis mutant deltaF508-CFTR.
Cell Physiol Biochem. 2009; 24: 347-60.
Wagner C, Kurtz L, Schweda F, Simon AM, Kurtz A
Connexin 37 is dispensable for the control of the renin system and for positioning of renin-producing cells in the kidney.
Pflugers Arch. 2009 Nov;459(1):151-8
Winklmeier, A., Weyand, M., Schreier, C., Kalbitzer, H. R. and Kremer, W.
Crystallization and preliminary X-ray diffraction studies of the tetramerization domain derived from the human potassium channel Kv1.3.
A. Crystal. F65, 688-691.
Aguiari G, Trimi V, Bogo M, Mangolini A, Szabadkai G, Pinton P, Witzgall R, Harris PC, Borea PA, Rizzuto R, del Senno L.
Novel role for polycystin-1 in modulating cell proliferation through calcium oscillations in kidney cells.
Cell Prolif. 2008 Jun;41(3):554-73.
Allen AM, O'Callaghan EL, Hazelwood L, Germain S, Castrop H, Schnermann J, Bassi JK.
Distribution of cells expressing human renin-promoter activity in the brain of a transgenic mouse.
Brain Res. 2008 Sep 24. [Epub ahead of print]
Bachhuber T, Almaca J, AlDehni F, Mehta A, Amaral M, Schreiber R, and Kunzelmann K.
Regulation of the epithelial Na+ channel by protein kinase CK2.
J Biol Chem 2008, 283: 13225-13232.
Banas MC*, BANAS B*, Hudkins KL, Wietecha TA, Iyoda M, Bock E, Hauser P, Pippin JW, Shankland SJ, Smith KD, Stoelcker B, Liu G, Gröne HJ, Krämer BK, Alpers CE
TLR4 links podocytes with the innate immune system to mediate glomerular injury
J Am Soc Nephrol. 19(4): 704-13, 2008 (*geteilte Erstautorenschaft)
Barro Soria R, Schreiber R, and Kunzelmann K.
Bestrophin 1 and 2 are components of the Ca2+ activated Cl- conductance in mouse airways.
BBA 2008, 1783: 1993-2000.
Bergler T, Stoelcker B, Jeblick R, Reinhold SW, Wolf K, Riegger GA, Krämer BK.
High osmolality induces the kidney-specific chloride channel CLC-K1 by a serum and glucocorticoid-inducible kinase 1 MAPK pathway.
Kidney Int. 2008 Jul 9.
Bruhl, H, Mack, M, Niedermeier, M, Lochbaum, D, Scholmerich, J and Straub, RH.
Functional expression of the chemokine receptor CCR7 on fibroblast-like synoviocytes.
Rheumatology (Oxford) 2008. 47: 1771-1774.
Castrop H, Schnermann JB.
Isoforms of the renal Na/K/2Cl cotransporter NKCC2: Expression and Functional Significance.
Am J Physiol Renal Physiol. 2008 May 21.
Castrop H.
Modulation of Adenosine Receptor Expression in the Proximal Tubule: A novel Adaptive Mechanism to Regulate Renal Salt and Water Metabolism.
Am J Physiol Renal Physiol. 2008 May 21.
Denzel, A, Maus, UA, Gomez, MR, Moll, C, Niedermeier, M, Winter, C, Maus, R, Hollingshead, S, Briles, DE, Kunz-Schughart, LA, Talke, Y and Mack, M.
Basophils enhance immunological memory responses.
Nat Immunol 2008. 9: 733-742.
Felekkis KN, Koupepidou P, Kastanos E, Witzgall R, Bai CX, Li L, Tsiokas L, Gretz N, Deltas C.
Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2.
BMC Nephrol. 2008 Aug 25;9:10.
Grangeia A, Barro Soria R, Carvalho F, Damas AM, Mauricio AC, Kunzelmann K, Barros A, and Sousa M.
Molecular and Functional Characterization of CBAVD-Causing Mutations Located in CFTR Nucleotide-Binding Domains.
Cell Physiol Biochem 2008, 22: 79-92.
Gupta, S, Fuchs, B, Schulz-Maronde, S, Heitland, A, Escher, SE, Mack, M, Tillmann, HC, Braun, A, Forssmann, WG, Elsner, J and Forssmann, U.
Intravascular inactivation of CCR5 by n-Nonanoyl-CC chemokine ligand 14 and inhibition of allergic airway inflammation.
J Leukoc Biol 2008. 83: 765-773.
Handel, TM, Johnson, Z, Rodrigues, DH, Dos Santos, AC, Cirillo, R, Muzio, V, Riva, S, Mack, M, Deruaz, M, Borlat, F, Vitte, PA, Wells, TN, Teixeira, MM and Proudfoot, AE.
An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo.
J Leukoc Biol 2008. 84: 1101-1108.
Heitzmann D, Warth R.
Physiology and pathophysiology of potassium channels in gastrointestinal epithelia.
Physiol Rev. 2008 Jul;88(3):1119-82.
Hennig B, Schultheiss G, Kunzelmann K, and Diener M.
Ca( 2+ )-Induced Cl (-) Efflux at Rat Distal Colonic Epithelium.
J Membr.Biol. 2008, 221: 61-72.
Herold, S, Steinmueller, M, von Wulffen, W, Cakarova, L, Pinto, R, Pleschka, S, Mack, M, Kuziel, WA, Corazza, N, Brunner, T, Seeger, W and Lohmeyer, J.
Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand.
J Exp Med 2008. 205: 3065-3077.
Höcherl K, Schmidt C, Kurt B, Bucher M.
Activation of the PGI2/IP System Contributes to the Development of Circulatory Failure in a Rat Model of Endotoxic Shock.
Hypertension. 2008, 52(2):330-5.
Illek B, Maurisse R, Wahler L, Kunzelmann K, Fischer H, and Gruenert DC.
Cl Transport in Complemented CF Bronchial Epithelial Cells Correlates with CFTR mRNA Expression Levels.
Cell Biochem Biophys 2008, 22: 57-68.
Jacob VA, Harbaugh CM, Dietz JR, Fenton RA, Kim SM, Castrop H, Schnermann J, Knepper MA, Chou CL, Anderson SA.
Magnetic resonance imaging of urea transporter knockout mice shows renal pelvic abnormalities.
Kidney Int. 2008 Nov;74(9):1202-8.
Jakubzick, C, Tacke, F, Ginhoux, F, Wagers, AJ, van Rooijen, N, Mack, M, Merad, M and Randolph, GJ.
Blood Monocyte Subsets Differentially Give Rise to CD103+ and CD103- Pulmonary Dendritic Cell Populations.
J Immunol 2008. 180: 3019-3027.
Krämer BK, Bergler T, Stoelcker B, Waldegger S.
Mechanisms of Disease: the kidney-specific chloride channels ClCKA and ClCKB, the Barttin subunit, and their clinical relevance.
Nat Clin Pract Nephrol. 2008 Jan;4(1):38-46.
Mignot, G, Ullrich, E, Bonmort, M, Menard, C, Apetoh, L, Taieb, J, Bosisio, D, Sozzani, S, Ferrantini, M, Schmitz, J, Mack, M, Ryffel, B, Bulfone-Paus, S, Zitvogel, L and Chaput, N.
The critical role of IL-15 in the antitumor effects mediated by the combination therapy imatinib and IL-2.
J Immunol 2008. 180: 6477-6483.
Mildner, A, Djukic, M, Garbe, D, Wellmer, A, Kuziel, WA, Mack, M, Nau, R and Prinz, M.
Ly-6G+CCR2- myeloid cells rather than Ly-6ChighCCR2+ monocytes are required for the control of bacterial infection in the central nervous system.
J Immunol 2008. 181: 2713-2722.
Milenkovic VM, Langmann T, Schreiber R, Kunzelmann K, and Weber BHF.
Molecular evolution and functional divergence of the bestrophin protein family.
BMC Evolutionary Biology 2008, 8: 72-78.
Oppermann M, Friedman DJ, Faulhaber-Walter R, Mizel D, Castrop H, Enjyoji K, Robson SC, Schnermann JB.
Tubuloglomerular Feedback and Renin Secretion in NTPDase1/CD39-Deficient Mice.
Am J Physiol Renal Physiol. 2008 Feb 6.
Ousingsawat J, Spitzner M, Schreiber R, and Kunzelmann K.
Upregulation of colonic ion channels in APCMin/+ mice.
Pflügers Arch 2008, 456: 847-855.
Quinones, MP, Kalkonde, Y, Estrada, CA, Jimenez, F, Ramirez, R, Mahimainathan, L, Mummidi, S, Choudhury, GG, Martinez, H, Adams, L, Mack, M, Reddick, RL, Maffi, S, Haralambous, S, Probert, L, Ahuja, SK and Ahuja, SS.
Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt.
Mol Cell Neurosci 2008. 37: 96-109.
Schmid U, Stopper H, Schweda F, Queisser N, Schupp N
Angiotensin II induces DNA damage in the kidney
Cancer Res. 2008 Nov 15;68(22):9239-46
Schmidt C, Höcherl K, Kurt B, Bucher M.
Role of NF-kappaB-dependent induction of cytokines in the regulation of vasopressin V1A-receptors during cecal ligation and puncture-induced circulatory failure.
Crit Care Med. 2008, 36(8):2363-72.
Schreiber R, Castrop H, and Kunzelmann K.
Allergen induced airway hyperresponsiveness is absent in ecto-5´-nucleotidase (CD73) deficient mice.
Pflugers Arch 2008, 457: 431-440.
Schroeder, JA, Weingart, C, Coras, B, Hausser, I, Reinhold, S, Mack, M, Seybold, V, Vogt, T, Banas, B, Hofstaedter, F and Krämer, BK.
Ultrastructural evidence of dermal gadolinium deposits in a patient with nephrogenic systemic fibrosis and end-stage renal disease.
Clin J Am Soc Nephrol 2008. 3: 968-975.
Spitzner M, Martins JR, Barro Soria R, Ousingsawat J, Scheidt K, Schreiber R, and Kunzelmann K.
Eag1 and Bestrophin 1 are up-regulated in fast-growing colonic cancer cells.
J Biol Chem 2008, 283: 7421-7428.
Todorov VT, Desch M, Schubert T, Kurtz A.
The Pal3 promoter sequence is critical for the regulation of human renin gene transcription by PPAR{gamma}.
Endocrinology. 2008 Sep;149(9):4647-57. Epub 2008 May 15.
Varga, G, Ehrchen, J, Tsianakas, A, Tenbrock, K, Rattenholl, A, Seeliger, S, Mack, M, Roth, J and Sunderkoetter, C.
Glucocorticoids induce an activated, anti-inflammatory monocyte subset in mice that resembles myeloid-derived suppressor cells.
J Leukoc Biol 2008. 84: 644-650.
Wagner C.
Function of connexins in the renal circulation.
Kidney Int. 2008 Mar;73(5):547-55.
Weingart, C, Nelson, PJ, Krämer, BK and Mack, M.
Dose dependent effects of platelet derived chondroitinsulfate A on the binding of CCL5 to endothelial cells.
BMC Immunol 2008. 9: 72.
Witzgall R.
Nail-patella syndrome.
Chapter 11, pp. 173-178. In: Molecular and Genetic Basis of Renal Disease. By D. B. Mount, M. R. Pollak (ed.). Saunders Elsevier (2008)
Witzgall R.
Are renal proximal tubular epithelial cells constantly prepared for an emergency? Focus on "The proliferation capacity of the renal proximal tubule involves the bulk of differentiated epithelial cells".
Am J Physiol Cell Physiol. 2008 Jan;294(1):C1-3.
Witzgall R.
How are podocytes affected in nail-patella syndrome?
Pediatr Nephrol. 2008 Jul;23(7):1017-20.
Yahiaoui, L, Gvozdic, D, Danialou, G, Mack, M and Petrof, BJ.
CC family chemokines directly regulate myoblast responses to skeletal muscle injury.
J Physiol 2008. 586: 3991-4004.
Amaral MD and Kunzelmann K.
Molecular Targeting of CFTR as a Therapeutic Approach to Cystic Fibrosis.
Trends Pharmacol Sci. 2007, 28: 334-341.
Banas MC, Parks WT, Hudkins KL, BANAS B, Holdren M, Iyoda M, Wietecha TA, Kowalewska J, Liu G, Alpers CE.
Localization of TGF-beta Signaling Intermediates Smad2, -3, -4, and -7 in Developing and Mature Human and Mouse Kidney
J Histochem Cytochem. 55(3): 275-85, 2007
Bloch M, Ousingsawat J, Simon R, Schraml P, Gasser TC, Mihatsch MJ, Kunzelmann K, Bubendorf L.
KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer.
Oncogene. 2007 Apr 12;26(17):2525-34
Brühl, H, Cihak, J, Plachy, J, Kunz-Schughart, L, Niedermeier, M, Denzel, A, Rodriguez Gomez, M, Talke, Y, Luckow, B, Stangassinger, M and Mack, M.
Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis.
Arthritis Rheum 2007. 56: 2975-2985.
Castrop H.
Mediators of tubuloglomerular feedback regulation of glomerular filtration: ATP and adenosine.
Acta Physiol (Oxf). 2007 Jan;189(1):3-14.
Conrad, SM, Strauss-Ayali, D, Field, AE, Mack, M and Mosser, DM.
Leishmania-Derived Murine Monocyte Chemoattractant Protein 1 Enhances the Recruitment of a Restrictive Population of CC Chemokine Receptor 2-Positive Macrophages.
Infect Immun 2007. 75: 653-665.
Conrad, SM, Strauss-Ayali, D, Field, AE, Mack, M and Mosser, DM.
Leishmania-Derived Murine Monocyte Chemoattractant Protein 1 Enhances the Recruitment of a Restrictive Population of CC Chemokine Receptor 2-Positive Macrophages.
Infect Immun 2007. 75: 653-665.
Endele S, Klein S, Richter S, Molter T, Amann K, Klanke B, Witzgall R, Johnson RL, Hilgers KF, Winterpacht A.
Renal phenotype in heterozygous Lmx1b knockout mice (Lmx1b (+/-)) after unilateral nephrectomy.
Transgenic Res. 2007 Dec;16(6):723-9. Epub 2007 Jul 27.
Feliciangeli S, Bendahhou S, Sandoz G, Gounon P, Reichold M, Warth R, Lazdunski M, Barhanin J, Lesage F.
Does Sumoylation Control K2P1/TWIK1 Background K(+) Channels?
Cell. 2007 Aug 10;130(3):563-9.
Gronwald, W., Brunner, K., Kirchhöfer, R., Trenner, J., Neidig, K. P. and Kalbitzer, H. R.
AUREMOL-RFAC-3D, combination of R-factors and their use for automated quality assessment of protein solution structures.
J Biomol NMR. 2007 Jan;37(1):15-30.
Hautmann M, Friis UG, Desch M, Todorov V, Castrop H, Segerer F, Otto C, Schutz G, Schweda F.
Pituitary Adenylate Cyclase-Activating Polypeptide Stimulates Renin Secretion via Activation of PAC1 Receptors.
J Am Soc Nephrol. 2007 Apr;18(4):1150-6. Epub 2007 Mar 14.
Hayo Castrop, Mona Oppermann, Diane Mizel, Yuning Huang, Robert Faulhaber-Walter, Yvonne Weiss, Lee S. Weinstein, Min Chen, Stephane Germain, Huiyan Lu, Dan Ragland, Daniel M. Schimel, Jurgen Schnermann.
Skeletal abnormalities and extra-skeletal ossification in mice with restricted Gsα deletion caused by a renin promoter-Cre transgene.
Cell Tissue Res. 2007 (in press).
Heitzmann D, Derand R, Jungbauer S, Bandulik S, Sterner C, Schweda F, Elwakil AE, Lalli E, Guy N, Mengual R, Reichold M, Tegtmeier I, Bendahhou S, Gomez-Sanchez CE, Isabel Aller M, Wisden W, Weber A, Lesage F, Warth R, Barhanin J.
Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis.
EMBO J. 2007 Nov 22.
Heitzmann D, Warth R.
No potassium, no acid: K+ channels and gastric acid secretion.
Physiology (Bethesda). 2007 Oct;22:335-41.
Kalbitzer, H. R., Kremer, W., Schumann, F., Spörner, M. and Gronwald, W.
Kap. 7 Elucidation of protein-protein and protein-ligand interactions by NMR spectroscopy.
(2007) In Protein Reviews, Vol. 5, “Protein interactions - Biophysical approaches for the study of complex reversible systems” (Peter Schuck, ed.), pp 189 to 230, Springer Verlag Heidelberg.
Krüger B, Böger CA, Obed A, Farkas S, Hoffmann U, BANAS B, Fischereder M, Krämer BK
RANTES/CCL5 polymorphisms as a risk factor for recurrent acute rejection
Clin Transplant. 21(3): 385-90, 2007
Kunzelmann K, Milenkovic VM, Spitzner M, Soria RB, Schreiber R.
Calcium-dependent chloride conductance in epithelia: is there a contribution by Bestrophin?
Pflugers Arch. 2007 Mar 15; [Epub ahead of print]
Kunzelmann K, Sun J, Meanger J, King NJ, Cook DI.
Inhibition of airway Na+ transport by respiratory syncytial virus.
J Virol. 2007 Feb 7; [Epub ahead of print]
Kurtz A, Eckardt KU.
Hematopoiesis and the kidney.
The Kidney (eds. Alpern RJ and Hebert SC), Elsevier, 2008, pp 2681-2718.
Kurtz L, Schweda F, de Wit C, Kriz W, Witzgall R, Warth R, Sauter A, Kurtz A, Wagner C.
Lack of Connexin 40 Causes Displacement of Renin-Producing Cells from Afferent Arterioles to the Extraglomerular Mesangium.
J Am Soc Nephrol. 2007 Feb 28.
[Pubmed] [Editorial]
Matzdorf C, Kurtz A, Höcherl K.
COX-2 activity determines the level of renin expression but is dispensable for acute upregulation of renin expression in rat kidneys.
Am J Physiol Renal Physiol. 2007, 292(6):F1782-1790.
Maus, UA, Backi, M, Winter, C, Srivastava, M, Schwarz, MK, Ruckle, T, Paton, JC, Briles, D, Mack, M, Welte, T, Maus, R, Bohle, RM, Seeger, W, Rommel, C, Hirsch, E, Lohmeyer, J and Preissner, KT.
Importance of Phosphoinositide 3-Kinase {gamma} in the Host Defense Against Pneumococcal Infection.
Am J Respir Crit Care Med 2007. 175: 958-966.
Mildner, A, Schmidt, H, Nitsche, M, Merkler, D, Hanisch, UK, Mack, M, Heikenwalder, M, Bruck, W, Priller, J and Prinz, M.
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions.
Nat Neurosci 2007. 10: 1544-1553.
Oppermann M, Hansen PB, Castrop H, Schnermann JB.
Vasodilatation of afferent arterioles and paradoxical increase of renal vascular resistance by furosemide in mice.
Am J Physiol Renal Physiol. 2007 May 9; [Epub ahead of print]
Oppermann M, Mizel D, Kim SM, Chen L, Faulhaber-Walter R, Huang Y, Li C, Deng C, Briggs J, Schnermann J, Castrop H.
Renal Function in Mice with Targeted Disruption of the A Isoform of the Na-K-2Cl Co-Transporter.
J Am Soc Nephrol. 2007 Jan 10; [Epub ahead of print]
Ousingsawat J, Spitzner M, Puntheeranurak S, Terracciano L, Tornillo L, Bubendorf L, Kunzelmann K, and Schreiber R.
Expression of voltage gated potassium channels in human and mouse colonic carcinoma.
Clinical Cancer Research 2007, 13: 824-831.
Puntheeranurak S, Schreiber R, Spitzner M, Ousingsawat J, Krishnamra N, Kunzelmann K.
Control of ion transport in mouse proximal and distal colon by prolactin.
Cell Physiol Biochem. 2007;19(1-4):77-88.
Rascle A, Suleiman H, Neumann T, Witzgall R.
Role of Transcription Factors in Podocytes.
Nephron Exp Nephrol 2007;106:e60–e66
DOI: 10.1159/000101794
Sauter A, Machura K, Neubauer B, Kurtz A, Wagner C.
Development of renin expression in the mouse kidney.
Kidney Int. 2007 Sep 26; [Epub ahead of print], doi:10.1038/sj.ki.5002571.
Schmidt C, Höcherl K, Bucher M.
Cytokine-mediated regulation of urea transporters during experimental endotoxemia.
Am J Physiol Renal Physiol. 2007, 292(5):F1479-1489.
Schmidt C, Höcherl K, Schweda F, Bucher M.
Proinflammatory cytokines cause downregulation of renal chloride entry pathways during sepsis.
Crit Care Med. 2007, 35(9): 2110-2119.
[Pubmed] [Editorial]
Schmidt C, Höcherl K, Schweda F, Kurtz A, Bucher M.
Regulation of renal sodium transporters during severe inflammation.
J Am Soc Nephrol. 2007, 18(4):1072-1083.
Schumann, F. H, Riepl, H., Maurer, T., Gronwald, W., Neidig, K. P., and Kalbitzer, H. R.
Combined chemical shift changes and amino acid specific chemical shift mapping of protein-protein interactions.
J Biomol NMR. 2007 Dec;39(4):275-89.
Schweda F, Friis U, Wagner C, Skott O, Kurtz A.
Renin release.
Physiology (Bethesda). 2007 Oct;22:310-9.
Sousa M, Ousingsawat J, Seitz R, Puntheeranurak S, Regalado A, Schmidt A, Grego T, Jansakul C, Amaral MD, Schreiber R, Kunzelmann K.
An extract from the medicinal plant Phyllanthus acidus and its isolated compounds induce airway chloride secretion: A potential treatment for cystic fibrosis.
Mol Pharmacol. 2007 Jan;71(1):366-76
Sousa M, Ousingsawat J, Seitz R, Puntheeranurak S, Regalado A, Schmidt A, Grego T, Jansakul C, Amaral MD, Schreiber R, Kunzelmann K.
An extract from the medicinal plant Phyllanthus acidus and its isolated compounds induce airway chloride secretion: A potential treatment for cystic fibrosis.
Mol Pharmacol. 2007 Jan;71(1):366-76. Epub 2006 Oct 25.
Suleiman H, Heudobler D, Raschta AS, Zhao Y, Zhao Q, Hertting I, Vitzthum H, Moeller MJ, Holzman LB, Rachel R, Johnson R, Westphal H, Rascle A, Witzgall R.
The podocyte-specific inactivation of Lmx1b, Ldb1 and E2a yields new insight into a transcriptional network in podocytes.
Dev Biol. 2007 Apr 15;304(2):701-12. Epub 2007 Jan 18.
Tacke, F, Alvarez, D, Kaplan, TJ, Jakubzick, C, Spanbroek, R, Llodra, J, Garin, A, Liu, J, Mack, M, van Rooijen, N, Lira, SA, Habenicht, AJ and Randolph, GJ.
Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques.
J Clin Invest 2007. 117: 185-194.
Todorov VT, Desch M, Schmitt-Nilson N, Todorova A, Kurtz A.
Peroxisome proliferator-activated receptor-gamma is involved in the control of renin gene expression.
Hypertension. 2007 Nov;50(5):939-44. Epub 2007 Sep 4.
[Pubmed] [Editorial]
Tsou, CL, Peters, W, Si, Y, Slaymaker, S, Aslanian, AM, Weisberg, SP, Mack, M and Charo, IF.
Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites.
J Clin Invest 2007. 117: 902-909.
Wagner C, de Wit C, Gerl M, Kurtz A, Höcherl K.
Increased expression of cyclooxygenase 2 contributes to aberrant renin production in connexin 40-deficient kidneys.
Am J Physiol Regul Integr Comp Physiol. 2007 Nov;293(5):R1781-6.
Wagner C, de Wit C, Kurtz L, Grunberger C, Kurtz A, Schweda F.
Connexin40 is Essential for the Pressure Control of Renin Synthesis and Secretion.
Circ Res. 2007 Jan 25.
[Pubmed] [Editorial]
Winter, C, Taut, K, Langer, F, Mack, M, Briles, DE, Paton, JC, Maus, R, Srivastava, M, Welte, T and Maus, UA.
FMS-Like Tyrosine Kinase 3 Ligand Aggravates the Lung Inflammatory Response to Streptococcus pneumoniae Infection in Mice: Role of Dendritic Cells.
J Immunol 2007. 179: 3099-3108.
Winter, C, Taut, K, Srivastava, M, Langer, F, Mack, M, Briles, DE, Paton, JC, Maus, R, Welte, T, Gunn, MD and Maus, UA.
Lung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host defense to Streptococcus pneumoniae infection in mice: role of the CCL2-CCR2 axis.
J Immunol 2007. 178: 5828-5838.
Witzgall R.
TRPP2 channel regulation.
Handb Exp Pharmacol. 2007;(179):363-75.
Ab E, Atkinson AR, Banci L, Bertini I, Ciofi-Baffoni S, Brunner K, Diercks T, Dötsch V, Engelke F, Folkers GE, Griesinger C, Gronwald W, Günther U, Habeck M, de Jong RN, Kalbitzer HR, Kieffer B, Leeflang BR, Loss S, Luchinat C, Marquardsen T, Moskau D, Neidig KP, Nilges M, Piccioli M, Pierattelli R, Rieping W, Schippmann T, Schwalbe H, Travé G, Trenner J, Wöhnert J, Zweckstetter M, Kaptein R.
NMR in the SPINE Structural Proteomics project.
Acta Crystallogr D Biol Crystallogr. 2006 Oct;62(Pt 10):1150-61.
Banzi M, Aguiari G, Trimi V, Mangolini A, Pinton P, Witzgall R, Rizzuto R, del Senno L.
Polycystin-1 promotes PKCalpha-mediated NF-kappaB activation in kidney cells.
Biochem Biophys Res Commun. 2006 Nov 17;350(2):257-62. Epub 2006 Sep 18.
Bohm M, Stadlthanner K, Gruber P, Theis FJ, Lang EW, Tome AM, Teixeira AR, Gronwald W, Kalbitzer HR.
On the use of simulated annealing to automatically assign decorrelated components in second-order blind source separation.
IEEE Trans Biomed Eng. 2006 May;53(5):810-20.
Brunner K, Gronwald W, Trenner JM, Neidig KP, Kalbitzer HR.
A general method for the unbiased improvement of solution NMR structures by the use of related X-ray data, the AUREMOL-ISIC algorithm.
BMC Struct Biol. 2006 Jun 26;6:14.
Castrop H, Lorenz JN, Hansen PB, Friis U, Mizel D, Oppermann M, Jensen BL, Briggs J, Skøtt O, Schnermann J.
Contribution of the basolateral isoform of the Na-K-2Cl- cotransporter (NKCC1/BSC2) to renin secretion.
Am J Physiol Renal Physiol. 2005 Dec;289(6):F1185-92.
Castrop H, Oppermann M, Weiss Y, Huang Y, Mizel D, Lu H, Germain S, Schweda F, Theilig F, Bachmann S, Briggs J, Kurtz A, Schnermann J.
Reporter gene recombination in juxtaglomerular granular and collecting duct cells by human renin promoter-Cre recombinase transgene.
Physiol Genomics. 2006, 25:277-285.
Crane, IJ, Xu, H, Wallace, C, Manivannan, A, Mack, M, Liversidge, J, Marquez, G, Sharp, PF and Forrester, JV.
Involvement of CCR5 in the passage of Th1-type cells across the blood-retina barrier in experimental autoimmune uveitis.
J Leukoc Biol 2006. 79: 435-443.
Dawson PA, Pirlo KJ, Steane SE, Kunzelmann K, Chien YJ, and Markovich D.
Molecular cloning and characterization of the mouse Na+ sulfate cotransporter gene (Slc13a4): structure and expression.
Genes Genet Syst 2006, 81: 265-272.
Gallagher AR, Hoffmann S, Brown N, Cedzich A, Meruvu S, Podlich D, Feng Y, Konecke V, de Vries U, Hammes HP, Gretz N, Witzgall R.
A Truncated Polycystin-2 Protein Causes Polycystic Kidney Disease and Retinal Degeneration in Transgenic Rats.
J Am Soc Nephrol. 2006 Oct;17(10):2719-2730. Epub 2006 Aug 30.
Grünberger C, Obermayer B, Klar J, Kurtz A, Schweda F.
The Calcium Paradoxon of Renin Release. Calcium Suppresses Renin Exocytosis by Inhibition of Calcium-Dependent Adenylate Cyclases AC5 and AC6.
Circ Res. 2006 Nov 24;99(11):1197-206. Epub 2006 Oct 26.
Herold, S, von Wulffen, W, Steinmueller, M, Pleschka, S, Kuziel, WA, Mack, M, Srivastava, M, Seeger, W, Maus, UA and Lohmeyer, J.
Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules.
J Immunol 2006. 177: 1817-1824.
Hoffmann U, BANAS B, Krüger B, Banas M, Bergler T, Böger C, Kammerl M, Obed A, Rümmele P, Segerer S, Riegger GA, Krämer BK
SDF-1 expression is elevated in chronic human renal allograft rejection
Clin Transplant. 20(6): 712-8, 2006
Hoffmann U, Segerer S, Rümmele P, Krüger B, Pietrzyk M, Hofstädter F, BANAS B, Krämer BK
Expression of the chemokine receptor CXCR3 in human renal allografts -a prospective study
Nephrol Dial Transplant. 21(5): 1373-81, 2006
Huber TB, Schermer B, Muller RU, Hohne M, Bartram M, Calixto A, Hagmann H, Reinhardt C, Koos F, Kunzelmann K, Shirokova E, Krautwurst D, Harteneck C, Simons M, Pavenstadt H, Kerjaschki D, Thiele C, Walz G, Chalfie M, Benzing T.
Inaugural Article: Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels.
Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17079-86. Epub 2006 Nov 1.
Köppler, B, Cohen, C, Schlöndorff, D and Mack, M.
Differential mechanisms of microparticle transfer to B cells and monocytes: anti-inflammatory properties of microparticles.
Eur J Immunol 2006. 36: 648-660.
Kunzelmann K, Scheidt K, Scharf B, Ousingsawat J, Schreiber R, Wainwright BJ, and McMorran B.
Pseudomonas flagellin inhibits Na+ transport in airway epithelia.
FASEB J 2006, 20: 545-546.
Kunzelmann K, Spitzner M, Ousingsawat J, Martins JR, and Schreiber R.
Expression von Ionenkanälen beim Kolonkarzinom: Neue diagnostische und therapeutische Möglichkeiten?
Onkologie heute 2006, 2: 18-21.
Kurtz A, Schweda F.
Osmolarity-induced renin secretion from kidneys: evidence for readily releasable renin pools.
Am J Physiol Renal Physiol. 2006, 290:F797-F 805.
[Pubmed] [Editorial]
Mahad, D, Callahan, MK, Williams, KA, Ubogu, EE, Kivisakk, P, Tucky, B, Kidd, G, Kingsbury, GA, Chang, A, Fox, RJ, Mack, M, Sniderman, MB, Ravid, R, Staugaitis, SM, Stins, MF and Ransohoff, RM.
Modulating CCR2 and CCL2 at the blood-brain barrier: relevance for multiple sclerosis pathogenesis.
Brain 2006. 129: 212-223.
Oppermann M, Mizel D, Huang G, Li C, Deng C, Theilig F, Bachmann S, Briggs J, Schnermann J, and Castrop H.
Macula Densa Control of Renin Secretion and Preglomerular Resistance in Mice with Selective Deletion of the B Isoform of the Na,K,2Cl Co-Transporter.
J Am Soc Nephrol 17:2143-2152,2006.
Pelucchi B, Aguiari G, Pignatelli A, Manzati E, Witzgall R, Del Senno L, Belluzzi O.
Nonspecific cation current associated with native polycystin-2 in HEK-293 cells.
J Am Soc Nephrol. 2006 Feb;17(2):388-97. Epub 2006 Jan 5.
Reinhold SW, Vitzthum H, Filbeck T, Wolf K, Lattas C, Riegger GA, Kurtz A,Krämer BK.
Gene expression of 5-, 12-, and 15-lipoxygenases and leukotriene receptors along the rat nephron.
Am J Physiol Renal Physiol. 2006, 290:F864-F872.
Rodriguez-Barbero A, Dorado F, Velasco S, Pandiella A, BANAS B, Lopez-Novoa JM
TGF-beta1 induces COX-2 expression and PGE(2) synthesis through MAPK and PI3K pathways in human mesangial cells
Kidney Int. 70(5): 901-9, 2006
Schmidt C, Höcherl K, Bucher M.
Regulation of renal glucose transporters during severe inflammation.
Am J Physiol Renal Physiol. 2007, 292(2):F804-811.
Seifarth, C, Mack, M, Steinlicht, S, Hahn, EG and Lohmann, T.
Transient chemokine receptor blockade does not prevent, but may accelerate type 1 diabetes in prediabetic NOD mice.
Horm Metab Res 2006. 38: 167-171.
Spitzner M, Ousingsawat J, Scheidt K, Kunzelmann K, and Schreiber R.
Voltage-gated K+ channels support proliferation of colonic carcinoma cells.
FASEB J. 2007 Jan;21(1):35-44
Stadlthanner K, Tome AM, Theis FJ, Lang EW, Gronwald W, Kalbitzer HR.
Separation of water artefacts in 2D NOESY protein spectra using congruent matrix pencils.
Neurocomp. 2006;96, 497-522.
Stenstad, H, Ericsson, A, Johansson-Lindbom, B, Svensson, M, Marsal, J, Mack, M, Picarella, D, Soler, D, Marquez, G, Briskin, M and Agace, WW.
Gut associated lymphoid tissue primed CD4+ T cells display CCR9 dependent and independent homing to the small intestine.
Blood 2006. 107: 3447-3454.
Stumpf A, Almaca J, Kunzelmann K, Wenners-Epping K, Huber SM, Häberle J, Falk S, Dübbers A, Walte M, Oberleithner H, and Schillers H.
IADS, a decomposition product of DIDS, activates a cation conductance in human erythrocytes and Xenopus laevis oocytes.
Cell Physiol Biochem 2006, 18: 243-252.
Weingart, C, Leingartner, T, Bergler, T, Kruger, B, Boger, C, Mack, M, Banas, B and Krämer, BK.
Increase in renal vascular resistance after intake of cyclosporin A and tacrolimus and reversal by nitroglycerin spray: a study in patients with stable renal allograft function.
Int J Clin Pharmacol Ther 2006. 44: 422-427.
Wörnle M*, BANAS B*, Merkle M, Henger A, Roeder M, Blattner S, Bock E, Kretzler M, Gröne HJ, Schlöndorff D.
Novel role of toll-like receptor 3 in hepatitis C-associated glomerulonephritis
Am J Pathol. 168(2): 370-85, 2006 (*geteilte Erstautorenschaft)